cleavable

UV Cleavable Biotin-PEG2-Azide, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].

Azido-C3-UV-biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

MC-Gly-Gly-Phe is a cleavable linker. MC-Gly-Gly-Phe can be used for antibody-drug conjugates (ADC).

Boc-C16-COOH is a alkyl-chain-based PROTAC linker. Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Val-cit-PAB-OH is an ADC linker that is cleavable.

Azide-C2-SS-C2-biotin is a cleavable biotinylated reagent that is an ADC linker for the synthesis of antibody-coupled reactive molecules.

Aminooxy-PEG4-alcohol is both a non-cleavable 4-unit PEG ADC linker and a PEG-based PROTAC linker.

Fmoc-Ala-Ala-Asn(Trt)-OH is a cleavable linker vital in ADC synthesis. Fmoc-Ala-Ala-Asn(Trt)-OH joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

N3-C4-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

PC Biotin-PEG3-alkyne is an ADC linker, cleavable 3-unit PEG, which can also be used to synthesize antibody drug conjugates (ADCs).

CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. .

Mal-PEG1-Val-Cit-OH is a cleavable one-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Fmoc-PEA (Example 1-2) is a used as a cleavable linker for antibody-drug conjugates (ADC).

DSP Crosslinker is a cleavable ADC linker, used in antibody-drug conjugates (ADCs) synthesis[1].

DBCO-Sulfo-NHS ester sodium is a cleavable linker predominantly employed in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-Val-Cit-PABC-PNP is a cleavable linker for antibody-drug conjugate (ADC) synthesis[1].

Azide-PEG5-Tos is a cleavable PEG linker consisting of five units, employed for the synthesis of antibody-drug conjugates (ADCs)[1].

Mal-PEG8-Val-Cit-PAB-MMAE is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Aminoethyl-SS-ethylalcohol (Compound 3) is an Alkyl-Chain-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminoethyl-SS-ethylalcohol is also a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Sulfo-MBS Crosslinker is a non-cleavable, water-soluble, heterobifunctional protein crosslinking reagent. It is commonly used to crosslink haptens to carrier proteins and enzymes to antibodies.

Gly-Gly-Gly-PEG3-TCO is a cleavable three-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Propargyl-PEG3-acid is a non-cleavable (3-unit PEG) ADC linker. Propargyl-PEG3-acid is also a PEG-based PROTAC linker used to synthesize 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA and Propargyl-PEG3-acid[1].

DBCO-PEG4-Maleimide is a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-Amide-PEG5-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in PROTAC synthesis[1]. NH2-PEG6-Boc is also a non-cleavable 6-unit PEG ADC linker used in antibody-drug conjugates(ADCs) synthesis[2].

PEG4-aminooxy-MMAF is a drug-linker conjugate designed for antibody-drug conjugates (ADC) that exhibits potent antitumor activity. It incorporates MMAF, a powerful antitubulin agent, connected through a non-cleavable PEG4 linker[1].

Mal-PEG4-VC-PAB-DMEA is a cleavable ADC linker that incorporates a Maleimide moiety. It is employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Phe-Lys(Trt)-PAB is a cathepsin-cleavable linker utilized in the development of antibody-drug conjugates (ADCs)[1], serving as a crucial component for facilitating the release of therapeutic agents within targeted cells.

Azido-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

N3-PEG3-CH2CH2-Boc is a cleavable 3 unit polyethylene glycol (PEG) ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. This compound also functions as a PEG- and alkyl/ether-based PROteolysis TArgeting Chimera (PROTAC) linker, suitable for the construction of PROTAC molecules[2].

Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable 2-unit polyethylene glycol (PEG) based ADC linker utilized in the construction of antibody-drug conjugates (ADCs)[1].

20-(tert-Butoxy)-20-oxoicosanoic acid is a alkyl-chain-based PROTAC linker. 20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label. PEG Linkers can be used in the synthesis of PROTACs.

Azido-PEG3-maleimide is a PEG-based PROTAC linker primarily used for the synthesis of PROTACs[1]. Additionally, it serves as a cleavable 3-unit PEG ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[2].

DBCO-PEG3-oxyamine is a non-cleavable 3-unit polyethylene glycol linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fmoc-Ala-Ala-Asn-PABC-PNP is a peptide cleavable ADC linker[1].

Azidoethyl-SS-ethylamine is a cleavable linker compound employed for the synthesis of antibody-drug conjugates (ADCs)[1].

Boc-Val-Cit-OH is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.

Mal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin and its derivative cytotoxic molecule[1].

sulfo-SPDB is a cleavable linker vital in ADC synthesis. sulfo-SPDB joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Boc-C14-COOH is a alkyl-chain-based PROTAC linker. Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Bis-PEG9-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

NHS-SS-biotin is a cleavable linker vital in ADC synthesis. NHS-SS-biotin joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Azido-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Val-Cit is a cleavable ADC linker. Val-Cit is used in the synthesis of antibody-drug conjugates (ADCs).

Bis-PEG25-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Tetrazine-PEG5-SS-amine is a cleavable 5-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Propargyl-PEG4-thiol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Fmoc-Gly-Gly-Phe-OtBu is a cleavable ADC linker. Fmoc-Gly-Gly-Phe-OtBu can be used in the synthesis of antibody-drug conjugates (ADCs).