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Ligand for E3 Ligase

Cat. No. Product name CAS No. Purity Chemical Structure
T29106 VH032 1448188-62-2 98%
VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs...
T18661 (S,R,S)-AHPC-C10-NH2 dihydrochloride 2341796-75-4 98%
(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based ...
T18822 Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride 2245697-85-0 98%
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker...
T17913 (S,R,S)-AHPC-PEG2-N3 2010159-45-0 98%
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC ...
T9360 N-(2,6-dioxopiperidin-3-yl)-4-nitrophthalimide 55003-81-1 98%
N-(2,6-dioxopiperidin-3-yl)-4-nitrophthalimide exhibit inhibition of CRBN.
T7752 (S,R,S)-AHPC-Me 1948273-02-6 98%
(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be use...
T5334 VL285 1448188-57-5 98%
VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.
T7758 Thalidomide-O-amido-PEG3-C2-NH2 TFA 1957236-21-3 98%
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-PEG3-C2-NH2 TFA incorporates the Thalidomide based ce...
T18066 Lenalidomide-OH 1416990-08-3 98%
Lenalidomide-OH is a ligand of cereblon (CRBN), serving as an analog to Lenalidomide for E3 ubiquitin ligase. It is utilized in the recruitment of CRBN protein. ...
T7763 Thalidomide-4-OH 5054-59-1 98%
Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker t...
T1642 Lenalidomide 191732-72-6 98%
Lenalidomide is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
T7756 E3 Ligase Ligand-Linker Conjugates 2 1818885-63-0 98%
E3 Ligase Ligand-Linker Conjugates 2 is a synthetic E3 ligase ligand-linker conjugate combining a Pomalidomide-based cereblon ligand and a 4-unit PEG linker.
T10765 Eragidomide 1860875-51-9 98%
Cereblon modulator 1 is a cereblon (CRBN) E3 ligase modulator. It specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.
T40028 (S,R,S)-AHPC 2055344-67-5 98%
(S,R,S)-AHPC is a VHL ligand that used in the recruitment of the VHL protein.
T18787 TD-165 2305936-56-3 98%
TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group...
T8824 CRBN modulator-1 2407829-65-4 98%
WUN29654 is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.
T7755 Thalidomide 4-fluoride 835616-60-9 98%
Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thali...
T9117 BSJ-4-116 2519823-34-6 98%
BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcript...
T14893 CC-885 1010100-07-8 98%
CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity.
T3549 Avadomide 1015474-32-4 98%
CC-122 is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
VH032
T29106
VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs...
(S,R,S)-AHPC-C10-NH2 dihydrochloride
T18661
(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based ...
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
T18822
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker...
(S,R,S)-AHPC-PEG2-N3
T17913
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC ...
N-(2,6-dioxopiperidin-3-yl)-4-nitrophthalimide
T9360
N-(2,6-dioxopiperidin-3-yl)-4-nitrophthalimide exhibit inhibition of CRBN.
(S,R,S)-AHPC-Me
T7752
(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be use...
VL285
T5334
VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.
Thalidomide-O-amido-PEG3-C2-NH2 TFA
T7758
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-PEG3-C2-NH2 TFA incorporates the Thalidomide based ce...
Lenalidomide-OH
T18066
Lenalidomide-OH is a ligand of cereblon (CRBN), serving as an analog to Lenalidomide for E3 ubiquitin ligase. It is utilized in the recruitment of CRBN protein. ...
Thalidomide-4-OH
T7763
Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker t...
Lenalidomide
T1642
Lenalidomide is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
E3 Ligase Ligand-Linker Conjugates 2
T7756
E3 Ligase Ligand-Linker Conjugates 2 is a synthetic E3 ligase ligand-linker conjugate combining a Pomalidomide-based cereblon ligand and a 4-unit PEG linker.
Eragidomide
T10765
Cereblon modulator 1 is a cereblon (CRBN) E3 ligase modulator. It specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.
(S,R,S)-AHPC
T40028
(S,R,S)-AHPC is a VHL ligand that used in the recruitment of the VHL protein.
TD-165
T18787
TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group...
CRBN modulator-1
T8824
WUN29654 is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.
Thalidomide 4-fluoride
T7755
Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thali...
BSJ-4-116
T9117
BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcript...
CC-885
T14893
CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity.
Avadomide
T3549
CC-122 is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
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