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E3 ligase Ligand 45
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Catalog No. T203443
E3ligaseLigand 45 is an E3 ligase ligand used in the synthesis of Setidegrasib, a PROTAC degrader for Ras.
E3 ligase Ligand 45
E3 ligase Ligand 45
😃Good
Catalog No. T203443
E3ligaseLigand 45 is an E3 ligase ligand used in the synthesis of Setidegrasib, a PROTAC degrader for Ras.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
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(S,R,S)-AHPC
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Pomalidomide Cited
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Thalidomide Cited
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Lenalidomide-Br
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Product Introduction
Bioactivity
Chemical Properties
| Description | E3ligaseLigand 45 is an E3 ligase ligand used in the synthesis of Setidegrasib, a PROTAC degrader for Ras. |
| Molecular Weight | 447.55 |
| Formula | C22H29N3O5S |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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