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Pack Size | Price | Availability | Quantity |
---|---|---|---|
200 mg | $50 | In Stock | |
500 mg | $97 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. |
Targets&IC50 | CRL4CRBN:250 nM (Kd) |
In vitro | Thalidomide selectively inhibits the production of tumor necrosis factor-alpha (TNF-α) in human monocytes stimulated by lipopolysaccharides and other agonists. Its suppression of TNF-α is mediated through the enhancement of mRNA degradation. Moreover, thalidomide exerts a direct effect on MM cell lines by inducing apoptosis and G1 phase growth arrest, as well as on patient MM cells resistant to melphalan, doxorubicin hydrochloride, and dexamethasone. |
In vivo | Administering 200mg/kg of Thalidomide resulted in the inhibition of vascularization in the corneal region within rabbits, with the inhibition rate ranging from 30% to 51% across three experiments. |
Alias | Thalomid, Sedoval |
Molecular Weight | 258.23 |
Formula | C13H10N2O4 |
Cas No. | 50-35-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 6.5 mg/mL (25 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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