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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $56 | In Stock | |
10 mg | $89 | In Stock | |
25 mg | $197 | In Stock | |
50 mg | $313 | In Stock | |
100 mg | $562 | In Stock | |
500 mg | $1,190 | In Stock |
Description | (S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory, anti-inflammatory, anticancer, anti-angiogenic, and pro-apoptotic activities, used in studying leprosy erythema nodosum and myeloma. |
In vitro | In U266 cells cultured with (S)-Thalidomide, a decrease in cell viability (IC50: 362 μM) was observed, reflecting a significant increase in apoptosis (for example, on the 3rd day at 200 μM: 40.3+/-3.1% vs. 3.2+/-0.4% on the 0th day; P<0.001). Furthermore, the expression profile of genes involved in angiogenesis and apoptosis changed, with the most significant alterations observed in the expression of apoptosis-related genes[1]. |
In vivo | Direct exposure of embryos to (S)-Thalidomide does indeed result in limb reduction defects in chick embryos. (S)-Thalidomide affects chick limb transplantation into host embryos in a dose-dependent manner. Moreover, S-thalidomide and S-EM12 are more teratogenic than R-thalidomide and R-EM12[2]. |
Alias | (S)-(-)-Thalidomide |
Molecular Weight | 258.23 |
Formula | C13H10N2O4 |
Cas No. | 841-67-8 |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (232.35 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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