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AR antagonist 1

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Purity:99.07%

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COA HNMR HPLC

AR antagonist 1

Catalog No. T10359Cas No. 1818885-54-9

AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.

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Pack Size	Price	Availability
1 mg	$133	In Stock
5 mg	$302	In Stock
10 mg	$447	In Stock
25 mg	$738	In Stock
50 mg	$987	In Stock
100 mg	$1,380	In Stock
500 mg	$2,790	In Stock
1 mL x 10 mM (in DMSO)	$289	In Stock

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Product Introduction

Bioactivity

Description	AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
Targets&IC50	Androgen receptor:
In vitro	AR antagonist 1 (compound 29) is the ligand for the target ligase of ARD-266, a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. AR antagonist 1 exhibits micromolar binding affinity to its E3 ligase complex and can be effectively used in designing potent and efficient PROTAC degraders.

Chemical Properties

Molecular Weight	278.78
Formula	C15H19ClN2O
Cas No.	1818885-54-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/mL (215.22 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5871 mL	17.9353 mL	35.8706 mL	179.3529 mL
5 mM	0.7174 mL	3.5871 mL	7.1741 mL	35.8706 mL
10 mM	0.3587 mL	1.7935 mL	3.5871 mL	17.9353 mL
20 mM	0.1794 mL	0.8968 mL	1.7935 mL	8.9676 mL
50 mM	0.0717 mL	0.3587 mL	0.7174 mL	3.5871 mL
100 mM	0.0359 mL	0.1794 mL	0.3587 mL	1.7935 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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