Shopping Cart
- Remove All
Your shopping cart is currently empty
AR antagonist 1
🥰Excellent
Catalog No. T10359Cas No. 1818885-54-9
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
AR antagonist 1
🥰Excellent
Purity: 99.07%
Catalog No. T10359Cas No. 1818885-54-9
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $78 | In Stock | |
| 5 mg | $181 | In Stock | |
| 10 mg | $268 | In Stock | |
| 25 mg | $443 | In Stock | |
| 50 mg | $592 | In Stock | |
| 100 mg | $828 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $173 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "AR antagonist 1"
Flutamide
Cited
SCH 13521
T048913311-84-7
Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
- $30
Size
QTY
CitedLenalidomide Cited
CC-5013
T1642191732-72-6
Lenalidomide (CC-5013) is an immunomodulator with oral activity. Lenalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN), which selectively ubiquitinates and degrades two lymphoid transcription factors, IKZF1 and IKZF3, via the CRBN-CRL4 ubiquitin ligase, and is commonly used in the synthesis of PROTAC products.
- $36
Size
QTY
CitedLenalidomide-Br
T180642093387-36-9
Lenalidomide-Br (Compound 41), a derivative of Lenalidomide, acts as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound can be conjugated to a protein ligand via a linker to create PROTACs, such as the PROTAC STAT3 degrader SD-36.
- $29
Size
QTY
S-23
S23, (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide
T207891010396-29-8
S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.
- $39
Size
QTY
Dehydroisoandrosterone 3-acetate
Prasterone acetate, DHEA acetate, Dehydroepiandrosterone acetate, Dehydroepiandrosterone 3-acetate, androstenolone acetate
T0856853-23-6
Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.
- $41
Size
QTY
Thalidomide Cited
Thalomid, Sedoval
T021350-35-1
Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
- $50
Size
QTY
CitedAllura Red AC
FD&C RED NO. 40, CI 16035, Allura Red
TN137025956-17-6
Allura Red AC (CI 16035) is a very important food azo dye used in the food, pharmaceutical, paper, cosmetic and textile industries.Allura Red AC promotes susceptibility to experimental colitis via mouse intestinal serotonin.
- $50
Size
QTY
Sunset Yellow FCF
Sunset yellow, Orange Yellow S, Food Yellow 3, CI 15985
TN22452783-94-0
Sunset Yellow FCF (Sunset yellow) is an orange azo dye with pH-dependent absorbance.Sunset Yellow FCF is used in food, cosmetics and pharmaceuticals.It is used as a colorant food additive in many food products.They may be cytotoxic and genotoxic, so care must be taken when using these materials as food additives.
- $41
Size
QTY
Octinoxate
Octyl methoxycinnamate, Octyl 4-methoxycinnamate, ethylhexyl methoxycinnamate, 2-Ethylhexyl 4-methoxycinnamate
T00735466-77-3
Octinoxate (Octyl 4-methoxycinnamate) is used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage,primarily as an ingredient in some sunscreens and lip balms. It is also used to reduce the appearance of scars.
- $41
Size
QTY
Ostarine
MK-2866, GTX-024, Enobosarm
T2408841205-47-8
Ostarine (MK-2866) is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostate growth, and muscle growth and strength. Mimicking testosterone's action, this agent may increase lean body mass, thereby ameliorating muscle wasting in the hypermetabolic state of cancer cachexia.
- $36
Size
QTY
Bicalutamide
ICI-176334
T038090357-06-5
Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.
- $32
Size
QTY
Pomalidomide Cited
CC-4047
T238419171-19-8
Pomalidomide (CC-4047) is an anti-angiogenic and immunomodulatory agent. Pomalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN) and is commonly used in the synthesis of PROTAC products.
- $52
Size
QTY
CitedSelect Batch
Purity:99.07%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266. |
| Targets&IC50 | Androgen receptor: |
| In vitro | AR antagonist 1 (compound 29) is the ligand for the target ligase of ARD-266, a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. AR antagonist 1 exhibits micromolar binding affinity to its E3 ligase complex and can be effectively used in designing potent and efficient PROTAC degraders. |
| Molecular Weight | 278.78 |
| Formula | C15H19ClN2O |
| Cas No. | 1818885-54-9 |
| Smiles | CC1(C)[C@H](N)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1 |
| Relative Density. | 1.18 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (215.22 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
VCaPtumorTarget Protein-binding MoietyPROTACLNCaPLinkerLigandsforTargetProteinforPROTACLigands for Target Protein for PROTACLigands for E3 LigaseLigandforE3LigaseLigand for E3 LigaseInhibitorinhibitE3 ligase-recruiting MoietycancerAR antagonist-1AR antagonist1AR antagonist 1AndrogenReceptorAndrogen Receptor
Preview
Related Tags: buy AR antagonist 1 | purchase AR antagonist 1 | AR antagonist 1 cost | order AR antagonist 1 | AR antagonist 1 chemical structure | AR antagonist 1 in vitro | AR antagonist 1 formula | AR antagonist 1 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.