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(S,R,S)-AHPC-Me hydrochloride

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Purity:99.18%

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COA HNMR HPLC

(S,R,S)-AHPC-Me hydrochloride

Catalog No. T13671Cas No. 1948273-03-7

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cells resistant to castration, exhibiting a remarkable DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, (S,R,S)-AHPC-Me hydrochloride serves as the VHL ligand derived from (S,R,S)-AHPC for the recruitment of von Hippel-Lindau (VHL) protein.

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Pack Size	Price	Availability
10 mg	$35	In Stock
25 mg	$57	In Stock
50 mg	$83	In Stock
100 mg	$122	In Stock

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Product Introduction

Bioactivity

Description

Alias

VHL ligand 2 hydrochloride, E3 ligase Ligand 1

Chemical Properties

Molecular Weight	481.05
Formula	C23H33ClN4O3S
Cas No.	1948273-03-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62 mg/mL(128.88 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0788 mL	10.3939 mL	20.7879 mL	103.9393 mL
5 mM	0.4158 mL	2.0788 mL	4.1576 mL	20.7879 mL
10 mM	0.2079 mL	1.0394 mL	2.0788 mL	10.3939 mL
20 mM	0.1039 mL	0.5197 mL	1.0394 mL	5.1970 mL
50 mM	0.0416 mL	0.2079 mL	0.4158 mL	2.0788 mL
100 mM	0.0208 mL	0.1039 mL	0.2079 mL	1.0394 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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