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(S,R,S)-AHPC-Me dihydrochloride

Catalog No. T13671L
Alias VHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride, (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)

(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound used in the synthesis of ARV-771. ARV-771 is a BET PROTAC degrader that relies on von Hippel-Landau (VHL) E3 ligase and exhibits potent degradation of BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound acts as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, facilitating the recruitment of von Hippel-Lindau (VHL) protein.

(S,R,S)-AHPC-Me dihydrochloride
Other Forms of (S,R,S)-AHPC-Me dihydrochloride:
(S,R,S)-AHPC-MeT77521948273-02-6
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(S,R,S)-AHPC-Me hydrochlorideT136711948273-03-7
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(S,R,S)-AHPC-Me dihydrochloride

Catalog No. T13671LAlias VHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride, (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound used in the synthesis of ARV-771. ARV-771 is a BET PROTAC degrader that relies on von Hippel-Landau (VHL) E3 ligase and exhibits potent degradation of BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound acts as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, facilitating the recruitment of von Hippel-Lindau (VHL) protein.
Pack SizePriceAvailabilityQuantity
5 mg$315 days
10 mg$435 days
25 mg$685 days
50 mg$985 days
100 mg$1435 days
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Product Introduction

Bioactivity
Description
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound used in the synthesis of ARV-771. ARV-771 is a BET PROTAC degrader that relies on von Hippel-Landau (VHL) E3 ligase and exhibits potent degradation of BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound acts as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, facilitating the recruitment of von Hippel-Lindau (VHL) protein.
AliasVHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride, (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
Chemical Properties
Molecular Weight517.51
FormulaC23H34Cl2N4O3S
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (193.23 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9323 mL9.6616 mL19.3233 mL96.6165 mL
5 mM0.3865 mL1.9323 mL3.8647 mL19.3233 mL
10 mM0.1932 mL0.9662 mL1.9323 mL9.6616 mL
20 mM0.0966 mL0.4831 mL0.9662 mL4.8308 mL
50 mM0.0386 mL0.1932 mL0.3865 mL1.9323 mL
100 mM0.0193 mL0.0966 mL0.1932 mL0.9662 mL

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Keywords

1948273-02-6 free base1948273-02-6E3 ligase Ligand 1AHPC-Me DihydrochlorideE3 ligase Ligand 1 Dihydrochloride(S,R,S)AHPCMe dihydrochlorideVHL ligand 2AHPC-MeVHL ligand 2 Dihydrochloride(S,R,S) AHPC Me dihydrochloride
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