Shopping Cart

Remove All

Your shopping cart is currently empty

(S,R,S)-AHPC-Me dihydrochloride

Resource Download

(S,R,S)-AHPC-Me dihydrochloride

Catalog No. T13671L

(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound used in the synthesis of ARV-771. ARV-771 is a BET PROTAC degrader that relies on von Hippel-Landau (VHL) E3 ligase and exhibits potent degradation of BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound acts as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, facilitating the recruitment of von Hippel-Lindau (VHL) protein.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
5 mg	$31	5 days
10 mg	$43	5 days
25 mg	$68	5 days
50 mg	$98	5 days
100 mg	$143	5 days

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description

Alias

VHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride, (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)

Chemical Properties

Molecular Weight	517.51
Formula	C23H34Cl2N4O3S
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (193.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9323 mL	9.6616 mL	19.3233 mL	96.6165 mL
5 mM	0.3865 mL	1.9323 mL	3.8647 mL	19.3233 mL
10 mM	0.1932 mL	0.9662 mL	1.9323 mL	9.6616 mL
20 mM	0.0966 mL	0.4831 mL	0.9662 mL	4.8308 mL
50 mM	0.0386 mL	0.1932 mL	0.3865 mL	1.9323 mL
100 mM	0.0193 mL	0.0966 mL	0.1932 mL	0.9662 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

1948273-02-6 free base1948273-02-6E3 ligase Ligand 1AHPC-Me DihydrochlorideE3 ligase Ligand 1 Dihydrochloride(S,R,S)AHPCMe dihydrochlorideVHL ligand 2AHPC-MeVHL ligand 2 Dihydrochloride(S,R,S) AHPC Me dihydrochloride

Related Tags: buy (S,R,S)-AHPC-Me dihydrochloride | purchase (S,R,S)-AHPC-Me dihydrochloride | (S,R,S)-AHPC-Me dihydrochloride cost | order (S,R,S)-AHPC-Me dihydrochloride | (S,R,S)-AHPC-Me dihydrochloride chemical structure | (S,R,S)-AHPC-Me dihydrochloride formula | (S,R,S)-AHPC-Me dihydrochloride molecular weight