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T1798 RITA RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 ...
T1919 Tenovin-1 Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T2243 Serdemetan Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
T2464 NSC319726 NSC319726, a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM).
T2707 Pifithrin-α Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
T2947 Indole-3-carbinol Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T2970 Rotenone Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)...
T3000 Magnolol Magnolol is a dual agonist of RXRα( EC50=10.4 µM) and PPARγ(EC50=17.7 µM). It blocks TNF-α-induced NF-KB activation.
T3184 Kevetrin hydrochloride Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
T3375 Verbascoside Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T3517 RO8994 RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding...
T3637 Pifithrin-β hydrobromide Pifithrin-β hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in m...
T3850 Luteolin-7-glucuronide Luteolin-7-Glucuronide possesses antioxidant activities.
T4325 COTI-2 COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.
T4414 PRIMA-1Met PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredo...
T5S0331 Isoliquiritin 1. Isoliquiritin has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin,liquiritin and isoliquirigenin inhibits the p53-dep...
T6909 NSC348884 NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct canc...
T6910 NSC59984 NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.
T6954 PRIMA-1 PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
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