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p53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), the Guardian of the Genome, phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog (originally thought to be, and often spoken of as, a single protein) is crucial in multicellular organisms, where it prevents cancer formation, and thus functions as a tumor suppressor. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.
Cat No. product name
T24730 Roslin 2 bromide Roslin 2 bromide 是一种 p53 再激活剂,可破坏 FAK 和 p53 的结合。 Roslin 2 bromide 具有抗癌作用。
T5S0331 Isoliquiritin 1. Isoliquiritin has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin inhibits the p53-dep...
T4414 Eprenetapopt PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredox...
T1798 RITA RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 i...
T4361 CBL0137 hydrochloride CBL0137 activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperone...
TN5263 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
T3375 Verbascoside Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T6909 NSC348884 NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer...
T1919 Tenovin-1 Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T3637 Pifithrin-β hydrobromide Pifithrin-β hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in mod...
T6210 Pifithrin-μ Pifithrin-μ is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.
T16522 Phenoxodiol Phenoxodiol is a synthetic analog of Genestein and activates the mitochondrial caspase system. Phenoxodiol causes cell cycle arrest in the G1/S phase of the cell...
T2970 Rotenone Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)....
T6610 NSC-207895 NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
T3000 Magnolol Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T3517 RO8994 RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
T4325 COTI-2 COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.
T2707 Pifithrin-α hydrobromide Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
T21527 HBX 41108 HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-depend...
T8480 Tenovin-6 Hydrochloride Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
T22980 MIRA-1 Restorer of wild-type p53 conformation/cellular function
TN2080 Pinoresinol Pinoresinol has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric...
T2243 Serdemetan Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
T2947 Indole-3-carbinol Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T7703 PK11007 PK11007 is an anti-p53 drug.
T21648 CP-31398 dihydrochloride CP 31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-t...
T2464 NSC319726 NSC319726, a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM).
TN1156 (-)-Curine (-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status.
TN1354 Aaptamine Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
TN1393 (-)-Anonaine (-)-Anonaine has some anticancer activity, it induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells, it induces DNA...
TN1379 Alphitolic acid Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotox...
TMA2474 δ-Tocotrienol Delta-tocotrienol is a potential angiogenic inhibitor, it (2.5-5 microM) can significantly suppress human colorectal adenocarcinoma cells (DLD-1-CM) -induced tub...
TN1688 Ginsenoside Rs3 Ginsenoside Rs3 induce apoptosis, is related to the elevations of p53 and p21WAF1 in the cells.
TN1617 Ergosta-4,6,8(14),22-tetraen-3-one Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatoce...
TN1875 Liriodenine Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can ...
TN2114 Pseudoginsenoside Rh2 Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
TN2123 Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
T9129 Benzonitrile, 3,3'-[(2-oxo-1,3-cyclohexanediylidene)dimethylidyne]bis- (9CI) Benzonitrile, 3,3'-[(2-oxo-1,3-cyclohexanediylidene)dimethylidyne]bis- (9CI) is an inhibitor of p53 with an IC50 value of 0.35 μM
T12472 Pifithrin-α, p-Nitro, Cyclic Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form inhibitor of p53.
T11092 DPBQ DPBQ is a factor that activates p53.
TN3404 Altholactone Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN3724 Cryptomoscatone D2 Cryptomoscatone D2 is a highly efficacious inhibitor of the G(2) checkpoint, and G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage ...
TN3719 Cristacarpin Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
TN3525 Boehmenan (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN3252 7alpha,15-Dihydroxydehydroabietic acid 7alpha,15-Dihydroxydehydroabietic acid may exhibit significant cytotoxic activity.
TN3152 6-Acetonyldihydrochelerythrine 6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
TN3931 Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
TN4107 Ganoderic acid X Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TN4213 Hirsutenone Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN4341 IVHD-valtrate VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
Roslin 2 bromide
T24730
Roslin 2 bromide 是一种 p53 再激活剂,可破坏 FAK 和 p53 的结合。 Roslin 2 bromide 具有抗癌作用。
Isoliquiritin
T5S0331
1. Isoliquiritin has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin inhibits the p53-dep...
Eprenetapopt
T4414
PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredox...
RITA
T1798
RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 i...
CBL0137 hydrochloride
T4361
CBL0137 activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperon...
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
TN5263
Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
Verbascoside
T3375
Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
NSC348884
T6909
NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cance...
Tenovin-1
T1919
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
Pifithrin-β hydrobromide
T3637
Pifithrin-β hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in mo...
Pifithrin-μ
T6210
Pifithrin-μ is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.
Phenoxodiol
T16522
Phenoxodiol is a synthetic analog of Genestein and activates the mitochondrial caspase system. Phenoxodiol causes cell cycle arrest in the G1/S phase of the cell...
Rotenone
T2970
Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)....
NSC-207895
T6610
NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
Magnolol
T3000
Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
RO8994
T3517
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
COTI-2
T4325
COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.
Pifithrin-α hydrobromide
T2707
Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
HBX 41108
T21527
HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-depend...
Tenovin-6 Hydrochloride
T8480
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a pote...
MIRA-1
T22980
Restorer of wild-type p53 conformation/cellular function
Pinoresinol
TN2080
Pinoresinol has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric...
Serdemetan
T2243
Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
Indole-3-carbinol
T2947
Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
PK11007
T7703
PK11007 is an anti-p53 drug.
CP-31398 dihydrochloride
T21648
CP 31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-t...
NSC319726
T2464
NSC319726, a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM).
(-)-Curine
TN1156
(-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status.
Aaptamine
TN1354
Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
(-)-Anonaine
TN1393
(-)-Anonaine has some anticancer activity, it induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells, it induces DNA...
Alphitolic acid
TN1379
Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotox...
δ-Tocotrienol
TMA2474
Delta-tocotrienol is a potential angiogenic inhibitor, it (2.5-5 microM) can significantly suppress human colorectal adenocarcinoma cells (DLD-1-CM) -induced tub...
Ginsenoside Rs3
TN1688
Ginsenoside Rs3 induce apoptosis, is related to the elevations of p53 and p21WAF1 in the cells.
Ergosta-4,6,8(14),22-tetraen-3-one
TN1617
Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatoce...
Liriodenine
TN1875
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can ...
Pseudoginsenoside Rh2
TN2114
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside
TN2123
Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
Benzonitrile, 3,3'-[(2-oxo-1,3-cyclohexanediylidene)dimethylidyne]bis- (9CI)
T9129
Benzonitrile, 3,3'-[(2-oxo-1,3-cyclohexanediylidene)dimethylidyne]bis- (9CI) is an inhibitor of p53 with an IC50 value of 0.35 μM
Pifithrin-α, p-Nitro, Cyclic
T12472
Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form inhibitor of p53.
DPBQ
T11092
DPBQ is a factor that activates p53.
Altholactone
TN3404
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
Cryptomoscatone D2
TN3724
Cryptomoscatone D2 is a highly efficacious inhibitor of the G(2) checkpoint, and G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage ...
Cristacarpin
TN3719
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in...
7alpha,15-Dihydroxydehydroabietic acid
TN3252
7alpha,15-Dihydroxydehydroabietic acid may exhibit significant cytotoxic activity.
6-Acetonyldihydrochelerythrine
TN3152
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
TN3931
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
Ganoderic acid X
TN4107
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
Hirsutenone
TN4213
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
IVHD-valtrate
TN4341
VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
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