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NSC348884

Catalog No. T6909Cas No. 81624-55-7

NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.

NSC348884

NSC348884

Purity: 99.91%
Catalog No. T6909Cas No. 81624-55-7
NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.
Pack SizePriceAvailabilityQuantity
2 mg$35In Stock
5 mg$56In Stock
10 mg$97In Stock
25 mg$190In Stock
50 mg$312In Stock
100 mg$450In Stock
500 mg$987In Stock
1 mL x 10 mM (in DMSO)$77In Stock
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Purity:99.91%
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Product Introduction

Bioactivity
Description
NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.
Targets&IC50
Nucleophosmin:1.7-4.0 μM
In vitro
NSC348884 disrupts a defined hydrophobic pocket required for oligomerization. NSC348884 disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53. NSC348884 induces apoptosis.
In vivo
In vivo invasion and intravasation (that is, the number of CTCs) are significantly inhibited after injection of NSC348884(as an inhibitor of NPM1 oligomerization) into the tumor-bearing mice. No significant difference in overall cell death is observed by histology in the treated tumors with the 4-hour brief treatments, suggesting that the inhibition seen is specific to migration.[2].
Chemical Properties
Molecular Weight636.79
FormulaC38H40N10
Cas No.81624-55-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (78.52 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5704 mL7.8519 mL15.7038 mL78.5188 mL
5 mM0.3141 mL1.5704 mL3.1408 mL15.7038 mL
10 mM0.1570 mL0.7852 mL1.5704 mL7.8519 mL
20 mM0.0785 mL0.3926 mL0.7852 mL3.9259 mL
50 mM0.0314 mL0.1570 mL0.3141 mL1.5704 mL

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