Anti-Lung Cancer Compound Library

Catalog No. L2190

Library Compound List Excel SDF

According to Global cancer statistics 2018, the global cancer burden is estimated to have risen to 18.1 million new cases and 9.6 million deaths in 2018. Nearly half of the new cases and more than half of the cancer deaths worldwide in 2018 are estimated to occur in Asia. Cancer of the lung is responsible for both the leading type of new cases (11.6% of the total cancer incidence) and the largest number of deaths (1.8 million deaths, 18.4% of the total) worldwide because of the poor prognosis for this cancer due to lack of effective therapy.

Treatment options for lung cancer include surgery, radiation therapy, chemotherapy, immunotherapy, targeted therapy and combination therapy. Therapeutic-modalities recommendations depend on several factors, including the type and stage of cancer. Despite the improvements in diagnosis and therapy made during the past 30 years, the prognosis for patients with lung cancer is still unsatisfactory. The responses to current standard therapies are poor except for the most localized cancers.

Targeted therapy and immunotherapy have changed the treatment paradigm of non-small cell lung cancer (NSCLC) and become the future direction for lung cancer therapy based on the major advances achieved recently. Targeted therapies focus on cancer cells by interrupting their growth and how they function and help reduce damage to healthy cells. However, while targeted therapy in NSCLC has provided disease control, the tumors inevitably develop drug resistance. With the advent of whole genome sequencing technology, we will have more understanding on the biological mechanism of the occurrence and development of NSCLC and the mechanism of drug resistance thus new generation of targeted therapy overcoming drug resistance can be designed and developed.

TargetMol’s Anti-Lung Cancer Compound Library collects 1735 compounds targeting lung cancer’s major signaling pathways or having anti-lung cancer therapeutic activity reported in literatures.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 1735 compounds with anti-lung cancer therapeutic activity or targeting lung cancer’s major signaling pathways, can be used for anti-lung cancer drug discovery and mechanism study；
Targets include EGFR, PI3K, FGFR, HER2, ALK, c-Met, etc.；
Some compounds have been in market or in clinical trials;
Detailed compound information with structure, target, and biological activity description；
NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

Apoptosis (346)

Autophagy (265)

NF-κB (208)

PI3K (171)

EGFR (158)

VEGFR (134)

PDGFR (93)

JAK (92)

Akt (89)

mTOR (88)

STAT (87)

FLT (84)

FGFR (79)

AMPK (69)

c-Kit (61)

c-Met/HGFR (61)

Antibacterial (57)

GSK-3 (56)

Endogenous Metabolite (53)

CDK (52)

ALK (48)

Src (47)

Wnt/beta-catenin (44)

HER (40)

DNA/RNA Synthesis (39)

ERK (37)

DNA-PK (37)

p53 (36)

COX (35)

IGF-1R (32)

TGF-beta/Smad (30)

S6 Kinase (30)

Parasite (29)

Antibiotic (29)

TNF (28)

Bcr-Abl (28)

Mitophagy (28)

Tyrosine Kinases (28)

p38 MAPK (27)

Reactive Oxygen Species (26)

HIV Protease (26)

DNA Alkylator/Crosslinker (25)

c-RET (25)

Aurora Kinase (25)

Raf (24)

TAM Receptor (24)

HDAC (23)

ATM/ATR (23)

Ferroptosis (22)

E1/E2/E3 Enzyme (22)

IL Receptor (21)

Pim (20)

Mdm2 (20)

MEK (20)

PDK (19)

JNK (19)

Potassium Channel (18)

Topoisomerase (18)

Microtubule Associated (18)

Influenza Virus (17)

Dehydrogenase (17)

PKC (16)

P450 (16)

DNA Alkylation (16)

Caspase (15)

Trk receptor (15)

PPAR (15)

BCL (15)

FAK (14)

Calcium Channel (13)

PI4K (13)

c-Fms (12)

HSP (12)

Lipoxygenase (12)

MAPK (11)

ROS (11)

PARP (11)

Antifungal (11)

IκB/IKK (11)

PKA (11)

MMP (11)

Chk (10)

Interleukin (10)

Casein Kinase (10)

Ras (9)

Nrf2 (9)

BTK (9)

5-HT Receptor (9)

ROS Kinase (9)

Nucleoside Antimetabolite/Analog (9)

PLK (8)

SARS-CoV (8)

NO Synthase (8)

PDE (8)

ROCK (8)

Tyrosinase (8)

Beta Amyloid (8)

Syk (8)

Phosphatase (8)

Histamine Receptor (8)

Adrenergic Receptor (8)

PTEN (7)

Estrogen/progestogen Receptor (7)

Epigenetic Reader Domain (7)

Sodium Channel (7)

Sirtuin (7)

CSF-1R (7)

TLR (7)

Adenosine Receptor (7)

Virus Protease (7)

HCV Protease (6)

NOS (6)

P-gp (6)

DNA (6)

HIF/HIF Prolyl-Hydroxylase (6)

HSV (6)

IAP (6)

Mitochondrial Metabolism (6)

GABA Receptor (6)

SIK (6)

Drug Metabolite (6)

AChR (6)

transporter (5)

Histone Methyltransferase (5)

Proteasome (5)

RAAS (5)

Retinoid Receptor (5)

Integrin (5)

Prostaglandin Receptor (5)

DHFR (5)

CaMK (5)

MELK (5)

Estrogen Receptor/ERR (5)

Glucocorticoid Receptor (5)

SGK (4)

MRP (4)

Dopamine Receptor (4)

NOD-like Receptor (NLR) (4)

HIF (4)

AChE (4)

CCR (4)

Tie-2 (4)

Gamma-secretase (4)

Ephrin Receptor (4)

Antioxidant (4)

Porcupine (4)

Hedgehog/Smoothened (4)

Antifolate (4)

Discoidin Domain Receptor (DDR) (3)

Anti-infection (3)

Histone Acetyltransferase (3)

Aromatase (3)

ribosome (3)

Antiviral (3)

NOD (3)

PGE Synthase (3)

HMG-CoA Reductase (3)

Ligand for E3 Ligase (3)

S1P Receptor (3)

Opioid Receptor (3)

Glutathione Peroxidase (3)

IFNAR (3)

Glucosidase (3)

Chloride channel (3)

Rho (3)

ATPase (3)

Serine Protease (3)

Aryl Hydrocarbon Receptor (3)

Transferase (3)

LDL (3)

Histone Demethylase (3)

DYRK (3)

Indoleamine 2,3-Dioxygenase (IDO) (2)

Reductase (2)

NMDAR (2)

Reverse Transcriptase (2)

Leukotriene Receptor (2)

IRE1 (2)

Glucokinase (2)

BACE (2)

Cannabinoid Receptor (2)

Androgen Receptor (2)

Phospholipase (2)

GHSR (2)

Serotonin Transporter (2)

HBV (2)

Progesterone Receptor (2)

Antifection (2)

DNA Methyltransferase (2)

Molecular Glues (2)

Ligands for Target Protein for PROTAC (2)

Carbonic Anhydrase (2)

ACK (2)

MLK (2)

STING (2)

PD-1/PD-L1 (2)

Smo (2)

cholecystokinin (2)

OXPHOS (2)

Kinesin (2)

Monoamine Oxidase (2)

CXCR (2)

VDA (1)

NPC1L1 (1)

PROTACs (1)

GTPase (1)

PKM (1)

CFTR (1)

Complement System (1)

ROR (1)

DAPK (1)

Gap Junction Protein (1)

IRAK (1)

Neurokinin receptor (1)

PERK (1)

NEDD8 (1)

CRM1 (1)

Amino Acids and Derivatives (1)

NADPH (1)

Na+/Ca2+ Exchanger (1)

NADPH-oxidase (1)

Sigma receptor (1)

YAP (1)

OCT (1)

LTR (1)

Melatonin Receptor (1)

Serine/threonin kinase (1)

c-Myc (1)

MNK (1)

LRRK2 (1)

PROTAC Linker (1)

Fatty Acid Synthase (1)

Bombesin Receptor (1)

Thioredoxin (1)

PAK (1)

FAAH (1)

Survivin (1)

Xanthine Oxidase (1)

Free radical scavengers (1)

Beta-Secretase (1)

KSP (1)

BCRP (1)

GluR (1)

cAMP (1)

Wee1 (1)

ATP Citrate Lyase (1)

DUB (1)

Aminopeptidase (1)

Guanylate cyclase (1)

ABC (1)

IDO (1)

Adenosine deaminase (1)

Hck (1)

cell cycle arrest (1)

Liver X Receptor (1)

CRISPR/Cas9 (1)

FXR (1)

PYK2 (1)

Glutaminase (1)

iGluR (1)

Monoamine Transporter (1)

Myosin (1)

RIP kinase (1)

Hippo pathway (1)

UGT (1)

MTH1 (1)

Methionine Adenosyltransferase (MAT) (1)

Pyroptosis (1)

hCE (1)

Hexokinase (1)

Melanin-concentrating Hormone Receptor (MCHR) (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty