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Anti-Lung Cancer Compound Library

Catalog No. L2190
  Library Compound List   Excel SDF

According to Global cancer statistics 2018, the global cancer burden is estimated to have risen to 18.1 million new cases and 9.6 million deaths in 2018. Nearly half of the new cases and more than half of the cancer deaths worldwide in 2018 are estimated to occur in Asia. Cancer of the lung is responsible for both the leading type of new cases (11.6% of the total cancer incidence) and the largest number of deaths (1.8 million deaths, 18.4% of the total) worldwide because of the poor prognosis for this cancer due to lack of effective therapy.

Treatment options for lung cancer include surgery, radiation therapy, chemotherapy, immunotherapy, targeted therapy and combination therapy. Therapeutic-modalities recommendations depend on several factors, including the type and stage of cancer. Despite the improvements in diagnosis and therapy made during the past 30 years, the prognosis for patients with lung cancer is still unsatisfactory. The responses to current standard therapies are poor except for the most localized cancers.

Targeted therapy and immunotherapy have changed the treatment paradigm of non-small cell lung cancer (NSCLC) and become the future direction for lung cancer therapy based on the major advances achieved recently. Targeted therapies focus on cancer cells by interrupting their growth and how they function and help reduce damage to healthy cells. However, while targeted therapy in NSCLC has provided disease control, the tumors inevitably develop drug resistance. With the advent of whole genome sequencing technology, we will have more understanding on the biological mechanism of the occurrence and development of NSCLC and the mechanism of drug resistance thus new generation of targeted therapy overcoming drug resistance can be designed and developed.

TargetMol’s Anti-Lung Cancer Compound Library collects 1566 compounds targeting lung cancer’s major signaling pathways or having anti-lung cancer therapeutic activity reported in literatures.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 1566 compounds with anti-lung cancer therapeutic activity or targeting lung cancer’s major signaling pathways, can be used for anti-lung cancer drug discovery and mechanism study;
  • Targets include EGFR, PI3K, FGFR, HER2, ALK, c-Met, etc.;
  • Some compounds have been in market or in clinical trials;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2190)

Library Composition

NF-κB (140)
PI3K (136)
EGFR (134)
VEGFR (90)
JAK (79)
PDGFR (68)
mTOR (66)
FGFR (63)
FLT (61)
STAT (61)
Akt (59)
c-Met/HGFR (58)
c-Kit (53)
AMPK (50)
ALK (45)
CDK (44)
GSK-3 (43)
Src (38)
Wnt/beta-catenin (34)
DNA/RNA Synthesis (31)
DNA-PK (31)
Tyrosine Kinases (29)
p53 (28)
HER (25)
ERK (25)
COX (24)
DNA Alkylation (24)
S6 Kinase (23)
ATM/ATR (23)
Bcr-Abl (22)
IGF-1R (22)
TAM Receptor (22)
Autophagy (20)
Raf (20)
c-RET (20)
Apoptosis (19)
TNF (18)
IL Receptor (18)
Topoisomerase (17)
HDAC (17)
MEK (16)
Aurora Kinase (15)
PARP (14)
Microtubule Associated (14)
TGF-beta/Smad (14)
PDK (13)
PKC (12)
HSP (11)
Caspase (11)
JNK (11)
AChR (11)
Trk receptor (10)
PPAR (10)
p38 MAPK (10)
P450 (10)
PKA (10)
5-HT Receptor (9)
Chk (8)
BTK (8)
PDE (8)
MAPK (8)
IκB/IKK (8)
Lipoxygenase (8)
Dehydrogenase (8)
HIV Protease (8)
Potassium Channel (8)
BCL (8)
ROS (8)
Mdm2 (7)
Syk (7)
FAK (7)
Estrogen/progestogen Receptor (7)
Glucocorticoid Receptor (7)
CSF-1R (7)
MMP (7)
c-Fms (7)
NOS (6)
Tyrosinase (6)
Calcium Channel (6)
PLK (5)
RAAS (5)
Retinoid Receptor (5)
Adrenergic Receptor (5)
Beta Amyloid (5)
Antioxidant (5)
Glucokinase (5)
Antifection (5)
Sodium Channel (5)
MRP (5)
TLR (5)
transporter (5)
Endogenous Metabolite (5)
DHFR (5)
PTEN (4)
Epigenetic Reader Domain (4)
Ras (4)
CaMK (4)
Nrf2 (4)
Adenosine Receptor (4)
SIK (4)
IAP (4)
Vitamin (4)
GABA Receptor (4)
Histamine Receptor (4)
ROCK (3)
HIF (3)
P-gp (3)
Prostaglandin Receptor (3)
Proteasome (3)
ACK (3)
Parasite (3)
Phosphatase (3)
Hedgehog/Smoothened (3)
Serine Protease (3)
HCV Protease (3)
HMG-CoA Reductase (3)
S1P Receptor (3)
ribosome (3)
MELK (3)
Ephrin Receptor (3)
Tie-2 (3)
Antibacterial (3)
Aromatase (3)
NOD (3)
E1/E2/E3 Enzyme (3)
Casein Kinase (3)
CXCR (3)
Dopamine Receptor (3)
MPO (3)
MLK (2)
MNK (2)
GluR (2)
DNA Alkylator/Crosslinker (2)
Sirtuin (2)
Carbonic Anhydrase (2)
NMDAR (2)
Antiviral (2)
GHSR (2)
HSV (2)
Hck (2)
ROR (2)
Antibiotic (2)
IDO (2)
Mitophagy (2)
cholecystokinin (2)
Chloride channel (2)
Integrin (2)
IRAK (2)
BACE (2)
Porcupine (2)
LDL (2)
LRRK2 (2)
PI4K (2)
Discoidin Domain Receptor (DDR) (2)
PYK2 (2)
Phospholipase (2)
Histone Demethylase (2)
Androgen Receptor (1)
Aminopeptidase (1)
ABC (1)
CCR (1)
Antifungal (1)
ATP Citrate Lyase (1)
Amino Acids and Derivatives (1)
Cannabinoid Receptor (1)
cAMP (1)
Wee1 (1)
ATPase (1)
Mitochondrial Metabolism (1)
VDA (1)
Pim (1)
DYRK (1)
DNA Methyltransferase (1)
CRM1 (1)
c-Myc (1)
CFTR (1)
cell cycle arrest (1)
PKM (1)
PERK (1)
Fatty Acid Synthase (1)
OXPHOS (1)
Opioid Receptor (1)
NPC1L1 (1)
Neurokinin receptor (1)
NADPH-oxidase (1)
NADPH (1)
MTH1 (1)
Monoamine Transporter (1)
FAAH (1)
Free radical scavengers (1)
UGT (1)
Reductase (1)
Transferase (1)
TACC (1)
Survivin (1)
SGK (1)
Serotonin Transporter (1)
SARS-CoV (1)
Rho (1)
Reverse Transcriptase (1)
Reactive Oxygen Species (1)
Gamma-secretase (1)
Melatonin Receptor (1)
LTR (1)
KSP (1)
Immunology & Inflammation related (1)
Histone Methyltransferase (1)
Hexokinase (1)
HBV (1)
GST (1)
IFNAR (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE