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Pyroptosis Compound Library

Catalog No. L8720
  Library Compound List   Excel SDF

Pyroptosis, also known as cellular inflammatory necrosis, is a programmed necrosis; it is manifested by the continuous distention of cells until the cell membrane ruptures, leading to the release of cellular contents and thus activating a strong inflammatory response. According to the activation mechanism, it can be divided into caspase-1-dependent classical pathway and caspase-1-independent (caspase-4/5/11) non-classical pathway. caspase-1 and caspase-4/5/11 cleaves the Gasdermin-D (GSDMD) protein and release its N-terminal structural domain, which binds membrane lipids and perforates the cell membrane, leading to distension by changes in cellular osmotic pressure until the cell membrane ruptures. Both pathways simultaneously induce cleavage of IL-1β and IL-18 precursors to form mature IL-1β and IL-18, which are released into the extracellular space and cause an inflammatory response. Studying the mechanism of Pyroptosis helps researchers to understand its role and development in related diseases such as infectious diseases, neurological diseases, cardiovascular diseases, cancer and other diseases.

The TargetMol Pyroptosis Compound Library is a collection of 1077 pyroptosis-related compounds that can be used in relevant studies.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • 1077 types of active small molecules associated with pyroptosis for high-throughput and high-content screening.
  • Targets include Caspase-1, Caspase-4, Caspase-5, Caspase-11, NLRP3, gasdermin D, etc.
  • Some compounds have been FDA-approved.
  • Detailed specifications, compound structures, target information, activity descriptions, etc.
  • Various detection techniques such as NMR, HPLC/LCMS to ensure the correct structure and high purity of the product and reduce false positives.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files
Request Library Compound List (L8720)

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..
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Library Composition

NF-κB (219)
Apoptosis (206)
Autophagy (176)
Reactive Oxygen Species (165)
COX (136)
mTOR (86)
p38 MAPK (83)
TNF (78)
Endogenous Metabolite (77)
Caspase (75)
IL Receptor (71)
Antibacterial (59)
TLR (56)
PI3K (53)
ROS (53)
AMPK (48)
JNK (46)
IκB/IKK (38)
Akt (37)
p53 (37)
ERK (34)
Interleukin (24)
HIV Protease (24)
Ferroptosis (24)
NOD (22)
NO Synthase (21)
RIP kinase (21)
E1/E2/E3 Enzyme (21)
Antifungal (21)
PPAR (21)
Antioxidant (20)
STAT (20)
Parasite (19)
Mdm2 (19)
BCL (18)
Influenza Virus (17)
DNA-PK (16)
NOD-like Receptor (NLR) (16)
IRAK (16)
Antibiotic (16)
P450 (16)
NOS (15)
PARP (15)
Mitochondrial Metabolism (14)
Calcium Channel (13)
Mitophagy (13)
MMP (12)
Lipoxygenase (11)
DNA/RNA Synthesis (11)
ROS Kinase (10)
MAPK (10)
CDK (10)
SARS-CoV (10)
Nrf2 (10)
EGFR (9)
Dehydrogenase (8)
Beta Amyloid (8)
Potassium Channel (8)
PKC (8)
JAK (8)
Virus Protease (8)
Tyrosinase (7)
Topoisomerase (7)
Src (7)
VEGFR (7)
ASK (7)
S6 Kinase (7)
ATM/ATR (7)
HIF/HIF Prolyl-Hydroxylase (7)
GABA Receptor (6)
Sirtuin (6)
Proteasome (6)
AChE (6)
Prostaglandin Receptor (6)
P-gp (6)
PGE Synthase (6)
IAP (6)
Wnt/beta-catenin (6)
5-HT Receptor (6)
AChR (6)
Estrogen/progestogen Receptor (6)
ALK (6)
Xanthine Oxidase (5)
TGF-beta/Smad (5)
Sodium Channel (5)
NADPH (5)
Anti-infection (5)
HSV (5)
HSP (5)
PDE (5)
c-Met/HGFR (5)
Casein Kinase (5)
MEK (4)
Antiviral (4)
transporter (4)
Free radical scavengers (4)
Trk receptor (4)
HDAC (4)
ATPase (4)
HBV (4)
PDK (4)
Glucocorticoid Receptor (4)
PKA (4)
Pyroptosis (4)
Antifection (3)
Bcr-Abl (3)
MAO (3)
Aurora Kinase (3)
CaMK (3)
RAAS (3)
Serine Protease (3)
Raf (3)
Reverse Transcriptase (3)
Carbonic Anhydrase (3)
Aryl Hydrocarbon Receptor (3)
Opioid Receptor (3)
Leukotriene Receptor (3)
Microtubule Associated (3)
HCV Protease (3)
IGF-1R (3)
TRP/TRPV Channel (3)
HER (3)
FAK (3)
GSK-3 (3)
FLT (3)
Histamine Receptor (3)
FGFR (3)
Tyrosine Kinases (3)
Glutathione Peroxidase (3)
Adenosine Receptor (3)
Retinoid Receptor (2)
HIF (2)
Aromatase (2)
c-Fms (2)
Epigenetic Reader Domain (2)
PDGFR (2)
Reductase (2)
c-Kit (2)
GST (2)
PERK (2)
Cannabinoid Receptor (2)
Phosphatase (2)
Phospholipase (2)
RANKL/RANK (2)
Glutathione reductase (2)
Syk (2)
Chloride channel (2)
Transferase (2)
Drug Metabolite (2)
Integrin (2)
DNA (2)
MLK (2)
Immunology/Inflammation related (2)
MRP (2)
SGLT (2)
DNA Alkylator/Crosslinker (2)
DUB (2)
Estrogen Receptor/ERR (2)
NADPH-oxidase (2)
IFNAR (2)
Complement System (2)
Androgen Receptor (1)
STING (1)
UGT (1)
RAR/RXR  (1)
Somatostatin (1)
Tie-2 (1)
Adenosine deaminase (1)
Annexin A (1)
Adrenergic Receptor (1)
Aminopeptidase (1)
RSV (1)
SIK (1)
Rho (1)
Serine/threonin kinase (1)
ATP Citrate Lyase (1)
ROCK (1)
AhR (1)
ROR (1)
S1P Receptor (1)
PTEN (1)
FXR (1)
BACE (1)
iGluR (1)
LTR (1)
LRRK2 (1)
Liver X Receptor (1)
Lipase (1)
LDL (1)
Dynamin (1)
FAAH (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
Fatty Acid Synthase (1)
FLAP (1)
Cysteine Protease (1)
Histone Acetyltransferase (1)
Hedgehog/Smoothened (1)
Hck (1)
Haspin Kinase (1)
gp120/CD4 (1)
Glucosidase (1)
Glucokinase (1)
Gap Junction Protein (1)
Gamma-secretase (1)
Discoidin Domain Receptor (DDR) (1)
Monoamine Oxidase (1)
Progesterone Receptor (1)
PAD (1)
BTK (1)
Platelet aggregation (1)
PKM (1)
PI4K (1)
cAMP (1)
CCR (1)
PAK (1)
PAI-1 (1)
PAFR (1)
CFTR (1)
CXCR (1)
cGAS (1)
Chk (1)
OCT (1)
Nucleoside Antimetabolite/Analog (1)
NPC1L1 (1)
c-Myc (1)
NMDAR (1)
c-RET (1)
Na+/Ca2+ Exchanger (1)
MyD88 (1)
OXPHOS (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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