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TargetMol | Compound Library

Pyroptosis Compound Library

Catalog No. L8720

Pyroptosis, also known as cellular inflammatory necrosis, is a programmed necrosis; it is manifested by the continuous distention of cells until the cell membrane ruptures, leading to the release of cellular contents and thus activating a strong inflammatory response. According to the activation mechanism, it can be divided into caspase-1-dependent classical pathway and caspase-1-independent (caspase-4/5/11) non-classical pathway. caspase-1 and caspase-4/5/11 cleaves the Gasdermin-D (GSDMD) protein and release its N-terminal structural domain, which binds membrane lipids and perforates the cell membrane, leading to distension by changes in cellular osmotic pressure until the cell membrane ruptures. Both pathways simultaneously induce cleavage of IL-1β and IL-18 precursors to form mature IL-1β and IL-18, which are released into the extracellular space and cause an inflammatory response. Studying the mechanism of Pyroptosis helps researchers to understand its role and development in related diseases such as infectious diseases, neurological diseases, cardiovascular diseases, cancer and other diseases. The TargetMol Pyroptosis Compound Library is a collection of 1066 pyroptosis-related compounds that can be used in relevant studies.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L8720

Pyroptosis Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • 1066 types of active small molecules associated with pyroptosis for high-throughput and high-content screening.
  • Targets include Caspase-1, Caspase-4, Caspase-5, Caspase-11, NLRP3, gasdermin D, etc.
  • Some compounds have been FDA-approved.
  • Detailed specifications, compound structures, target information, activity descriptions, etc.
  • Various detection techniques such as NMR, HPLC/LCMS to ensure the correct structure and high purity of the product and reduce false positives.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

NF-κB
Apoptosis
Autophagy
Reactive Oxygen Species
COX
mTOR
p38 MAPK
Caspase
TNF
IL Receptor
Endogenous Metabolite
Antibacterial
TLR
PI3K
ROS
AMPK
JNK
IκB/IKK
p53
Akt
ERK
NOD
Interleukin
HIV Protease
Ferroptosis
RIP kinase
NO Synthase
Mdm2
Antifungal
Antioxidant
PPAR
E1/E2/E3 Enzyme
Parasite
STAT
Bcl-2 Family
DNA-PK
Cytochromes P450
IRAK
PARP
Antibiotic
NOS
Influenza Virus
NOD-like Receptor (NLR)
Mitophagy
Calcium Channel
Mitochondrial Metabolism
MMP
Lipoxygenase
CDK
DNA/RNA Synthesis
MAPK
SARS-CoV
Nrf2
ROS Kinase
JAK
EGFR
Dehydrogenase
Virus Protease
PKC
Beta Amyloid
Src
VEGFR
Topoisomerase
ASK
ATM/ATR
GABA Receptor
Potassium Channel
S6 Kinase
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
Proteasome
Estrogen/progestogen Receptor
Wnt/beta-catenin
IAP
Cholinesterase (ChE)
PGE Synthase
P-gp
Prostaglandin Receptor
Sirtuin
ALK
HDAC
5-HT Receptor
AChR
c-Met/HGFR
PDE
HSV
Xanthine Oxidase
TGF-beta/Smad
Pyroptosis
Casein Kinase
Anti-infection
Sodium Channel
ATPase
NADPH
PKA
HBV
TRP/TRPV Channel
Glucocorticoid Receptor
Antiviral
HSP
Trk receptor
Free radical scavengers
transporter
Ligand for E3 Ligase
PDK
MEK
Carbonic Anhydrase
HCV Protease
Adenosine Receptor
RAAS
Histamine Receptor
Glutathione Peroxidase
GSK-3
Tyrosine Kinases
Serine Protease
Leukotriene Receptor
MAO
Aryl Hydrocarbon Receptor
Immunology/Inflammation related
Bcr-Abl
Raf
Antifection
Molecular Glues
Opioid Receptor
Aurora Kinase
IGF-1R
CaMK
Reverse Transcriptase
FGFR
FLT
Microtubule Associated
FAK
Chloride channel
Transferase
Integrin
DNA Alkylator/Crosslinker
Reductase
IFNAR
Phosphatase
MRP
Estrogen Receptor/ERR
RANKL/RANK
PDGFR
Epigenetic Reader Domain
DNA
DUB
GST
Retinoid Receptor
c-Fms
Aromatase
Phospholipase
HIF
Cannabinoid Receptor
Complement System
Syk
c-Kit
MLK
HER
PROTACs
NPC1L1
RAR/RXR
ROR
Dynamin
MyD88
LTR
BACE
Na+/Ca2+ Exchanger
PERK
Lipase
Tie-2
gp120/CD4
Progesterone Receptor
OCT
c-Myc
Rho
Hck
Serine/threonin kinase
Nucleoside Antimetabolite/Analog
Cysteine Protease
Liver X Receptor
FXR
Glucokinase
ROCK
Adrenergic Receptor
Amylase
iGluR
SIK
Annexin A
FLAP
UGT
PAFR
Haspin Kinase
LDL
Gamma-secretase
Drug Metabolite
NMDAR
Glucosidase
Fatty Acid Synthase
Hedgehog/Smoothened
PAK
FAAH
CCR
CXCR
PTEN
Somatostatin
Chk
PAD
cAMP
Indoleamine 2,3-Dioxygenase (IDO)
Androgen Receptor
SGLT
ATP Citrate Lyase
OXPHOS
Glutathione reductase
STING
LRRK2
Aminopeptidase
AIM2
cGAS
PAI-1
RSV
PI4K
Adenosine Deaminase
c-RET
Gap Junction Protein
Discoidin Domain Receptor (DDR)
Platelet aggregation
NADPH-oxidase
AhR
CFTR
PKM
S1P Receptor
Monoamine Oxidase
ADC Cytotoxin
BTK

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