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Pifithrin-α, p-Nitro, Cyclic

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Purity:99.97%

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COA HPLC HNMR

Pifithrin-α, p-Nitro, Cyclic

Catalog No. T12472Cas No. 60477-38-5

Pifithrin-α, p-Nitro, Cyclic (PFN-α) is a cell-permeable, active-form inhibitor of p53.

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Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$80	In Stock
10 mg	$128	In Stock
25 mg	$263	In Stock
50 mg	$428	In Stock
100 mg	$639	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Product Introduction

Bioactivity

Description	Pifithrin-α, p-Nitro, Cyclic (PFN-α) is a cell-permeable, active-form inhibitor of p53.
In vitro	Pifithrin-α, p-Nitro, Cyclic (PFN-α) significantly inhibits p53-induced cell death and p21/WAF1 expression in cortical neurons exposed to etoposide, requiring concentrations an order of magnitude lower than PFT-α[1].
In vivo	Intraocular administration of pifithrin-α at a concentration of 6 µM modestly enhances the survival of retinal ganglion cells (RGC), while it remains ineffective at 0.06 µM. Despite the observed in vitro benefits, pifithrin-α, p-Nitro, Cyclic (PFN-α) demonstrates no in vivo efficacy, even at the 6 µM concentration. Furthermore, pifithrin-α, p-Nitro, Cyclic exhibits a half-life (t1/2) of 6 hours under biological conditions[1].
Alias	PFN-α

Chemical Properties

Molecular Weight	299.35
Formula	C15H13N3O2S
Cas No.	60477-38-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 5 mg/mL (16.70 mM), Sonication is recommended.

DMF: 12.5 mg/mL (41.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF

	1mg	5mg	10mg	50mg
1 mM	3.3406 mL	16.7029 mL	33.4057 mL	167.0286 mL
5 mM	0.6681 mL	3.3406 mL	6.6811 mL	33.4057 mL
10 mM	0.3341 mL	1.6703 mL	3.3406 mL	16.7029 mL

DMF

	1mg	5mg	10mg	50mg
20 mM	0.1670 mL	0.8351 mL	1.6703 mL	8.3514 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc