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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
2 mg | $48 | In Stock | |
5 mg | $80 | In Stock | |
10 mg | $128 | In Stock | |
25 mg | $263 | In Stock | |
50 mg | $428 | In Stock | |
100 mg | $639 | In Stock | |
1 mL x 10 mM (in DMSO) | $79 | In Stock |
Description | Pifithrin-α, p-Nitro, Cyclic (PFN-α) is a cell-permeable, active-form inhibitor of p53. |
In vitro | Pifithrin-α, p-Nitro, Cyclic (PFN-α) significantly inhibits p53-induced cell death and p21/WAF1 expression in cortical neurons exposed to etoposide, requiring concentrations an order of magnitude lower than PFT-α[1]. |
In vivo | Intraocular administration of pifithrin-α at a concentration of 6 µM modestly enhances the survival of retinal ganglion cells (RGC), while it remains ineffective at 0.06 µM. Despite the observed in vitro benefits, pifithrin-α, p-Nitro, Cyclic (PFN-α) demonstrates no in vivo efficacy, even at the 6 µM concentration. Furthermore, pifithrin-α, p-Nitro, Cyclic exhibits a half-life (t1/2) of 6 hours under biological conditions[1]. |
Alias | PFN-α |
Molecular Weight | 299.35 |
Formula | C15H13N3O2S |
Cas No. | 60477-38-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 5 mg/mL (16.70 mM), Sonication is recommended. DMF: 12.5 mg/mL (41.76 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/DMF
DMF
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