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Glycometabolism Compound Library

Catalog No. L2520
  Library Compound List   Excel SDF

Glucose and glycogen are initial materials involved in the glycometabolism. A chronically irregular diet could result in the disorders of glycometabolism, which was manifested by the gradual deterioration of glucose tolerance over time, leading to the increased fasting blood glucose or impaired glucose tolerance. The clinical manifestations of glycometabolism-related disorder are hyperglycemia or hypoglycemia, which might eventually contribute to some serious diseases, such as diabetes, G6PD deficiency, obesity and malnutrition.

In addition, favored glycolysis under aerobic conditions (aerobic glycolysis), or the Warburg effect, the transition from oxidative phosphorylation to glycolysis, accompanied by the accumulation of lactate by-products in the surrounding microenvironment and 20-30 times faster rate of glucose metabolism than the complete oxidation of glucose in the mitochondria, represents the most typical change observed in the metabolism of cancer cells. Therefore, a key to selective killing of cancer cells lies in their dependence on glycolysis. Targeting tumor cell metabolism has become a successful approach to the prevention or treatment of cancer. Most efforts have focused on the use of small molecules to inhibit the function of metabolic enzymes, which has been comprehensively reviewed elsewhere. Increasing evidence supports many glycolytic enzymes and transporters as candidates for cancer treatment.

TargetMol’s Glycometabolism Compound Library collects 708 glycometabolism-related compounds, targeting GLUTs, Hexokinase(HK), Pyruvate Kinase(PK ), phosphofructokinase(PFK), IDH1/2, LDH, AMPK, etc. It is a powerful tool for research in glycometabolism-related disorders and cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • 708 glycometabolism-related comounds, can be used for HTS and HCT;
  • Targets contain GLUTs、Hexokinase(HK)、Pyruvate Kinase(PK)、phosphofructokinase(PFK)、IDH1/2、LDH、AMPK, etc.;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.
  • All compounds are in stock.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2520)

Library Composition

Apoptosis (117)
Autophagy (116)
PI3K (107)
Phosphatase (76)
PPAR (62)
mTOR (60)
AMPK (51)
Akt (44)
Glucokinase (40)
Endogenous Metabolite (36)
GSK-3 (35)
Dehydrogenase (32)
Antibacterial (30)
DNA-PK (25)
Carbonic Anhydrase (25)
p53 (23)
HIF/HIF Prolyl-Hydroxylase (21)
HIF (21)
NF-κB (19)
S6 Kinase (19)
Parasite (18)
ATM/ATR (18)
CDK (17)
IGF-1R (17)
PDK (16)
Antibiotic (16)
Mitochondrial Metabolism (16)
DPP-4 (15)
Glucocorticoid Receptor (14)
Ferroptosis (14)
Proteasome (14)
Reactive Oxygen Species (14)
COX (14)
SGLT (14)
transporter (14)
Reductase (11)
PKC (10)
Antifungal (10)
HIV Protease (9)
E1/E2/E3 Enzyme (9)
Isocitrate Dehydrogenase (IDH) (9)
Influenza Virus (9)
Wnt/beta-catenin (8)
P450 (8)
Mitophagy (8)
Tyrosinase (8)
Potassium Channel (8)
PKM (8)
Src (8)
VEGFR (7)
TNF (7)
PARP (7)
ERK (7)
PKA (7)
Virus Protease (7)
SGK (7)
NAMPT (6)
NADPH (6)
Calcium Channel (6)
MMP (6)
Mdm2 (6)
HSV (6)
ROCK (6)
PERK (5)
Chk (5)
MEK (5)
Lipoxygenase (5)
Histone Methyltransferase (5)
Casein Kinase (5)
STAT (5)
Interleukin (4)
FLT (4)
EGFR (4)
PDE (4)
PDGFR (4)
AChE (4)
FGFR (4)
ATPase (4)
JNK (4)
PI4K (4)
ALK (3)
Androgen Receptor (3)
p38 MAPK (3)
Sodium Channel (3)
NADPH-oxidase (3)
PTEN (3)
Chloride channel (3)
IL Receptor (3)
SIK (3)
Estrogen/progestogen Receptor (3)
c-Met/HGFR (3)
Adrenergic Receptor (3)
Aryl Hydrocarbon Receptor (3)
Hexokinase (3)
Sirtuin (3)
TRP/TRPV Channel (3)
Phosphorylase (3)
AhR (2)
Beta Amyloid (2)
AChR (2)
DNA/RNA Synthesis (2)
Epigenetic Reader Domain (2)
c-Fms (2)
Estrogen Receptor/ERR (2)
Anti-infection (2)
PAK (2)
BCL (2)
Antioxidant (2)
Integrin (2)
GluR (2)
Gamma-secretase (2)
Aurora Kinase (2)
Serine Protease (2)
HDAC (2)
GABA Receptor (2)
ATP Citrate Lyase (2)
Topoisomerase (2)
Microtubule Associated (2)
Tyrosine Kinases (2)
TGF-beta/Smad (2)
c-RET (2)
Raf (2)
MELK (2)
Bcr-Abl (2)
LRRK2 (2)
FAK (2)
Syk (2)
Trk receptor (1)
Proton pump (1)
Serine/threonin kinase (1)
Thrombin (1)
S1P Receptor (1)
Progesterone Receptor (1)
Prostaglandin Receptor (1)
Reverse Transcriptase (1)
PYK2 (1)
Retinoid Receptor (1)
ROS (1)
ABC (1)
PLK (1)
cell cycle arrest (1)
DNA Alkylator/Crosslinker (1)
DNA Alkylation (1)
DHFR (1)
Cysteine Protease (1)
CSF-1R (1)
Complement System (1)
c-Kit (1)
CaMK (1)
Fatty Acid Synthase (1)
Bombesin Receptor (1)
Beta-Secretase (1)
BACE (1)
Arginase (1)
Adenosine Receptor (1)
Adenosine deaminase (1)
ADC Cytotoxin (1)
Drug Metabolite (1)
Glucagon Receptor (1)
Phospholipase (1)
Immunology/Inflammation related (1)
NOS (1)
Myosin (1)
MRP (1)
MLK (1)
MAPK (1)
JAK (1)
IκB/IKK (1)
iGluR (1)
Glutaminase (1)
HSP (1)
Histone Demethylase (1)
Hedgehog/Smoothened (1)
HCV Protease (1)
Hck (1)
HBV (1)
Guanylate cyclase (1)
Glutathione Peroxidase (1)
YAP (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE