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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $34 | In Stock | |
5 mg | $55 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $197 | In Stock | |
50 mg | $297 | In Stock | |
100 mg | $449 | In Stock | |
1 mL x 10 mM (in DMSO) | $61 | In Stock |
Description | MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM. |
Targets&IC50 | p53:10μM, WRN helicase:20 µM |
In vitro | MIRA-1 induces p53 transcriptional transactivation of p21, MDM2, and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro with an IC50 of 10μM[1]. |
Alias | p53 Activator VIII, 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione, (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate, NSC 19630, WRN Helicase Inhibitor |
Molecular Weight | 183.16 |
Formula | C8H9NO4 |
Cas No. | 72835-26-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 20 mg/mL (109.19 mM) Ethanol: 20 mg/mL (109.19 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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