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Rifaximin
🥰Excellent
Catalog No. T1154Cas No. 80621-81-4
Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and bacterial cell growth.
Rifaximin
🥰Excellent
Purity: 99.18%
Catalog No. T1154Cas No. 80621-81-4
Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and bacterial cell growth.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 200 mg | $31 | In Stock | |
| 500 mg | $53 | In Stock | |
| 1 g | $81 | In Stock | |
| 5 g | $345 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $57 | In Stock |
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CitedSelect Batch
Purity:99.18%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and bacterial cell growth. |
| In vitro | Rifaximin exhibits broad-spectrum activity against aerobic and anaerobic Gram-positive and Gram-negative microorganisms.Rifaximin exhibits a low MIC against Gram-positive bacteria, with a dose range of 0.01 μg/mL to 0.5 μg/mL for MIC 90.Rifaximin binds to the β-subunit of the bacterial DNA-dependent RNA polymerase and inhibits the start of the chain of RNA synthesis. Rifaximin inhibits LPS-induced cytokine and chemokine expression by inhibiting NF-κB DNA binding activity.50 μM Rifaximin reduces changes in pro-inflammatory factor production induced by LPS stimulation in the IEC, such as TNF-α, IL-8, Rantes, and PGE2 in normal intestinal epithelial cells.100 μM Rifaximin is also shown to inhibit LPS-induced cytokine expression by inhibiting NF-κB DNA binding activity. μM Rifaximin effectively reduced the expression of TNFα, IL-8, MIP-3α and RANTES by lipopolysaccharide-induced stimulation. |
| In vivo | Rifaximin exhibits broad-spectrum activity against aerobic and anaerobic Gram-positive and Gram-negative microorganisms.Rifaximin exhibits a low MIC against Gram-positive bacteria, with a dose range of 0.01 μg/mL to 0.5 μg/mL for MIC 90.Rifaximin binds to the β-subunit of the bacterial DNA-dependent RNA polymerase and inhibits the start of the chain of RNA synthesis. Rifaximin inhibits LPS-induced cytokine and chemokine expression by inhibiting NF-κB DNA binding activity.50 μM Rifaximin reduces changes in pro-inflammatory factor production induced by LPS stimulation in the IEC, such as TNF-α, IL-8, Rantes, and PGE2 in normal intestinal epithelial cells.100 μM Rifaximin is also shown to inhibit LPS-induced cytokine expression by inhibiting NF-κB DNA binding activity. μM Rifaximin effectively reduced the expression of TNFα, IL-8, MIP-3α and RANTES by lipopolysaccharide-induced stimulation. |
| Molecular Weight | 785.88 |
| Formula | C43H51N3O11 |
| Cas No. | 80621-81-4 |
| Smiles | COC1\C=C/OC2(C)OC3=C(C2=O)C2=C(C(O)=C3C)C(O)=C(NC(=O)\C(C)=C/C=C\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C1=C2N=C2C=C(C)C=CN12 |
| Relative Density. | 1.36 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (63.62 mM)  Ethanol: 3 mg/mL (3.81 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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