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Urethane
🥰Excellent
Catalog No. T0051Cas No. 51-79-6
Alias Ethylurethane, Ethyl carbamate, Carbamic acid ethyl ester
Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes.
Urethane
🥰Excellent
Purity: 99.63%
Catalog No. T0051Alias Ethylurethane, Ethyl carbamate, Carbamic acid ethyl esterCas No. 51-79-6
Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $29 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Purity:99.63%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes. |
| Targets&IC50 | NMDAR:70 mM(EC50), α4β2 nAChR:114 mM(EC50), GABAA receptor:64 mM(EC50), Glycine receptor:46 mM(EC50), AMPA receptor:34 mM(EC50) |
| In vitro | urethane has a spectrum of action on ion channels, which is distinct from other anesthetics. It significantly potentiates the current responses of both GABAA and glycine receptors in a reversible and concentration-dependent manner. Conversely, urethane (10–300 mM) inhibits the responses of NMDA and AMPA receptors. Also, urethane potentiates the function of an nACh receptor and neuronal nicotinic acetylcholine, γ-aminobutyric acid A, and glycine receptors[3]. |
| In vivo | Urethane, a carcinogenic substance, is favored for acute in vivo electrophysiological experiments because it induces long-lasting steady level of anesthesia with muscle relaxation and minimally affects the autonomic and cardiovascular systems[2]. Urethane affects both inhibitory and excitatory systems but the magnitude of the alterations is less than that produced by other more selective anesthetics[3]. But also, Urethane anesthesia is usually restricted to terminal (acute) experiments due to its potential long-term toxicity[1]. |
| Alias | Ethylurethane, Ethyl carbamate, Carbamic acid ethyl ester |
| Molecular Weight | 89.09 |
| Formula | C3H7NO2 |
| Cas No. | 51-79-6 |
| Smiles | CCOC(N)=O |
| Relative Density. | 1.10 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (617.35 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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