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Kanamycin sulfate

🥰Excellent
Catalog No. T0793Cas No. 25389-94-0
Alias Ophtalmokalixan, Kanamycin monosulfate, Kanamycin A monosulfate

Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside antibiotic that interferes with protein synthesis by binding to the 70S ribosomal subunit of bacteria. Kanamycin sulfate exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as mycoplasmas.

Kanamycin sulfate

Kanamycin sulfate

🥰Excellent
Purity: 99.96%
Catalog No. T0793Alias Ophtalmokalixan, Kanamycin monosulfate, Kanamycin A monosulfateCas No. 25389-94-0
Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside antibiotic that interferes with protein synthesis by binding to the 70S ribosomal subunit of bacteria. Kanamycin sulfate exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as mycoplasmas.
Pack SizePriceAvailabilityQuantity
200 mg$41In Stock
1 mL x 10 mM (in H2O)$50In Stock
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Purity:99.96%
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Product Introduction

Bioactivity
Description
Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside antibiotic that interferes with protein synthesis by binding to the 70S ribosomal subunit of bacteria. Kanamycin sulfate exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as mycoplasmas.
In vitro
METHODS: Human cell lines HEK293, OVCAR8 and CA46 were treated with Kanamycin sulfate (0-1 mM) and cell viability was measured using the CCK-8 assay.
RESULTS: Kanamycin showed no cytotoxic effects in any of the cell lines. [1]
METHODS: Mycobacteria H37Rv, H2, H37RvR-PAS, Ravenel, Kirchbergand and BCG were treated with Kanamycin sulfate (0.1-100 µg/mL) for 2 weeks and tested for antibacterial activity.
RESULTS: Kanamycin showed good antimicrobial activity against various Mycobacterium species with MICs of 1 µg/mL and 5 µg/mL for Kirchbergand strains, respectively. [2]
In vivo
METHODS: To detect ototoxicity, Kanamycin sulfate (800 mg/kg) was administered subcutaneously to C57BL/6J mice twice daily for fifteen days.
RESULTS: Different ototoxic regimens were evaluated by ABR and DPOAE measurements before and after treatment. Sensory cell loss was quantified by counting hair cells in the cochlea. The study demonstrated that the Kanamycin ototoxicity regimen was safe, well tolerated, and detected early significant changes in hearing thresholds by DPOAE in a small group of mice. [3]
AliasOphtalmokalixan, Kanamycin monosulfate, Kanamycin A monosulfate
Chemical Properties
Molecular Weight582.58
FormulaC18H38N4O15S
Cas No.25389-94-0
SmilesOS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.1.3619 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 50 mg/mL (85.82 mM)
DMSO: Insoluble
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.7165 mL8.5825 mL17.1650 mL85.8251 mL
5 mM0.3433 mL1.7165 mL3.4330 mL17.1650 mL
10 mM0.1717 mL0.8583 mL1.7165 mL8.5825 mL
20 mM0.0858 mL0.4291 mL0.8583 mL4.2913 mL
50 mM0.0343 mL0.1717 mL0.3433 mL1.7165 mL

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