G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic, an inhibitor of protein synthesis with eukaryotic selectivity. G-418 disulfate blocks peptide synthesis by inhibiting peptide chain elongation.

Teicoplanin (MDL-507) is a semisynthetic glycopeptide antibiotic, used to treat Gram-positive bacteria.

Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B into hepatocytes. Cyclosporin B also

Bilanafos is an agent of Anti-Bacterial.

Bleomycin Sulfate (Blenoxane) is a glycopeptide antibiotic, an inhibitor of DNA synthesis. Bleomycin Sulfate causes DNA strand breaks but not RNA strand breaks. Bleomycin Sulfate has antitumor activity.

Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procyclins and inhibits calcineurin (IC50=7 nM).

Magainin 1 acetate is an antimicrobial peptide. Magainin 1 acetate exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria.

LAH4 acetate is the α-helical structure of the designed amphoteric peptide antibiotic, which is capable of complexing DNA, associating with the cell surface membrane and wrapped in the endosome, which is destroyed with the decrease of pH value. It has strong antibacterial, nucleic acid transfection and cell penetration activities. LAH4 acetate has high plasmid DNA transmission capacity. LAH4 acetate has a strong affinity for anions in bacterial membranes.

PGLa acetate is a 21-residue member of the magainin family of antibiotic peptides.

Murepavadin acetate is a potent and specific antibiotic for the treatment of bacterial infections cused by Pseudomonas aeruginosa. Murepavadin acetate targets the lipopolysaccharide transport portin D.

Thiostrepton (Alaninamide) is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in dermatologic disorders.

Vancomycin hydrochloride (Vancomycin HCl) is the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci.

A group of peptide antibiotics from BACILLUS brevis. Gramicidin (Gramicidine) C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN.

Polymyxin B Sulfate (Poly-RX) is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B Sulfate (Poly-RX) is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.

Colistin A is an antibiotic generated by certain strains of the bacteria Paenibacillus polymyxa. Colistin is a mixture of the cyclic polypeptides colistin A and B and belongs to the class of polypeptide antibiotics known as polymyxins. Colistin is effecti

Clovibactin, a novel antibiotic, effectively eradicates drug-resistant bacterial pathogens and demonstrates no discernible resistance. It is derived from uncultured soil bacteria [1].

Dermcidin-1L (human), an antibiotic peptide secreted by sweat glands, exhibits antimicrobial activity and is utilized in the research of inflammatory skin disorders [1].

Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, serves as a highly potent, specific antibiotic with remarkable antimicrobial activity against P. aeruginosa, demonstrated by MIC 50 and MIC 90 values of 0.12 mg/L. It uniquely targets the lipopolysaccharide transport protein D, showing potential for research on bacterial resistance [1] [2].

Linopristin is a streptogramin B class antibiotic. It is one of the components of the antibiotic combination NXL103.

Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic with activity against gram-positive bacteria. It is existed in the Actinoplanes spp.

Globomycin is a lipopeptide antibiotic and an inhibitor of signal peptidase II (LspA). It inhibits the processing of the prolipoprotein by binding irreversibly to the peptidase.

Arylomycin A2, a lipopeptide antibiotic, functions as a type I signal peptidase (SPase I) inhibitor. It exhibits antibacterial properties [1].

Friulimicin D, a lipopeptide antibiotic similar to Friulimicin B, is derived from the actinomycete Actinoplanes friuliensis [1].

Mipsagargin (G-202) is a new antibiotic that inhibits DNA biosynthesis.

Virginiamycin M1 (Pristinamycin IIA) is a macrocyclic lactone peptide antibiotic and is a member of the streptogramin A group of antibiotics.

CRAMP-18 (mouse) is an antibiotic peptide with demonstrated efficacy against Gram-negative bacteria, including S. typhimurium and P. aeruginosa, while exhibiting no hemolytic activity. This compound shows promise for research into antifungal, antibacterial, and antitumor applications [1] [2].

Lugdunin is an antibiotic peptide that disrupts membrane potential in bacteria, demonstrating activity against Gram-positive species including S. aureus, and effectively reducing skin and nasal colonization of this pathogen. Moreover, Lugdunin stimulates the production of LL-37 and CXCL8/MIP-2 in human keratinocytes and mouse skin [1].

Human β-defensin-3 (HβD-3) is an antibiotic antimicrobial peptide synthesized by epithelial cells. It exhibits potent antimicrobial properties and mitigates inflammatory cytokine responses. HβD-3 efficiently targets various microorganisms, displaying IC90 values ranging from 6 to 25 μg/ml.

Aurein 3.3 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].

Aurein 5.2 is an antibiotic antimicrobial peptide [1].

Zoptarelin doxorubicin, also known as AEZS-108, is an LHRH agonist. Zoptarelin doxorubicin is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R) that is conjugated to the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation

Cefilavancin (TD-1792), a potent glycopeptide-cephalosporin heterodimer antibiotic, exhibits effective activity against Gram-positive bacteria. It has been utilized in researching skin infections [1] [2] [3].

Balhimycin, a glycopeptide antibiotic produced through the fermentation broth of Amycolatopsis sp., exhibits anti-bacterial effects against staphylococci and anaerobes [1].

Friulimicin A, a lipopeptide antibiotic analogous to Friulimicin B, is isolated from the actinomycete Actinoplanes friuliensis [1].

Cecropin A is a naturally occurring, linear, cationic, 37-residue antimicrobial peptide.

Milbemycin oxime is a broad spectrum antiparasitic, used as a veterinary drug.

Colistin sulfate (Colistin sulfate (1066-17-7 free base)) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2.

Daptomycin (LY146032) is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.

Oritavancin diphosphate (LY333328 diphosphate) is a novel semisynthetic glycopeptide antibiotic which is being developed for the treatment of serious Gram-positive bacterial infections.

Aurein 1.2, an amphibian-derived peptide, exhibits both antibiotic and anticancer properties [1].

Gramicidin S (Gramicidin Soviet), a cationic cyclic peptide antibiotic, disrupts the membrane integrity of both Gram-positive and Gram-negative bacteria and inhibits cytochrome bd quinol oxidase [1].

Aurein 3.1 is an antibiotic antimicrobial peptide, whereas Aurein 2.6 demonstrates activity against Gram-positive bacteria, exhibiting minimum inhibitory concentrations (MIC) of 80 μM for M. luteus and 50 μM for S. aureus, S. epidermis, S. mutans, and B. subtilis [1] [2].

Aurein 2.6, an antibiotic antimicrobial peptide, exhibits activity against various Gram-positive bacteria with minimum inhibitory concentrations (MIC) of 25, 25, 30, 25, and 30 μM for M. luteus, S. aureus, S. epidermis, S. mutans, and B. subtilis, respectively [1][2].

Capreomycin is a polypeptide antibiotic originally isolated from S. capreolus. It is active against M. tuberculosis (MIC = 10 µg/ml). Capreomycin binds to both the 30S and 50S ribosomal subunits, inhibiting protein synthesis.

Cyclo-L-Trp-L-Trp is a broad-spectrum antifungal. It also induces a high degree of acetylation of histones.

PGLa TFA, a 21-residue antimicrobial peptide from the magainin family of antibiotic peptides found in frog skin and its secretions [1], serves as a representative member of this bioactive group.

Fusafungine, known commercially as Bioparox, Fusaloyos, and Locabiotal, serves as a potent antibiotic and anti-inflammatory agent effective in oral administration. It shows promise for research related to upper respiratory airways disease (URAD)[1][2].

Colistin A sulfate hydrate, a key constituent of the polymyxin antibiotic Colistin, effectively combats infections from challenging gram-negative bacteria [1].

LAH4 TFA, an alpha-helix of the designed amphipathic peptide antibiotic, demonstrates potent antimicrobial, nucleic acid transfection, and cell penetration capabilities, alongside high plasmid DNA delivery capacities. It also exhibits a strong affinity for anionic lipids present in the outer membrane of bacterial membranes [1] [2] [3].

Murepavadin is a highly potent, specific, macrocycle Pseudomonas antibiotic for the treatment of bacterial infections caused by Pseudomonas aeruginosa..