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Triclosan

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Catalog No. T1314Cas No. 3380-34-5
Alias Irgasan, Cloxifenolum

Triclosan (Irgasan) is an antibacterial and antifungal agent.

Triclosan

Triclosan

🥰Excellent
Purity: 100%
Catalog No. T1314Alias Irgasan, CloxifenolumCas No. 3380-34-5
Triclosan (Irgasan) is an antibacterial and antifungal agent.
Pack SizePriceAvailabilityQuantity
50 mg$41In Stock
100 mg$46In Stock
200 mg$79In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Triclosan (Irgasan) is an antibacterial and antifungal agent.
In vitro
cancer cells with triclosan at the physiologically related concentrations significantly increases the colony number of the cancer cells assessed by tumor formation assay. Triclosan-treated cells have a mesenchymal-like morphology and decrease the cell-to-cell adhesion. Triclosan-treated cells exhibit decreased E-cadherin while significantly up-regulated levels of EMT markers, namely N-cadherin, vimentin, snail and slug. Triclosan may potentiate cancer cells survival in detached condition and motility via the process of EMT[2].
In vivo
Triclosan plays a pathologic role in promoting tissue fibrogenesis, leading to liver carcinogenesis. It accelerates both HCC development and its long-term effects on liver damage, accompanied by fibrosis and inflammation in mice[1].
Cell Research
CV-1 cells are maintained in DMEM supplemented with 10% FBS, seeded in 96-well plates, and transfected with an expression vector containing a specific nuclear receptor and RXR, along with a luciferase reporter containing the appropriate DNA response element. The assay is first validated with known nuclear receptor ligands as positive controls. For the CAR ligand-binding assay, CV-1 cells are transiently transfected with the expression vector containing the Gal4 DNA-binding domain fused with the ligand-binding domain of murine or human CAR and cotransfected with the luciferase reporter plasmid, mh 100-luc. The day after the transfection, the positive compound of each nuclear receptor or TCS(Triclosan) is added and the cells are incubated for an additional 24 h. The luciferase activities are measured and normalized by β-gal activity.(Only for Reference)
AliasIrgasan, Cloxifenolum
Chemical Properties
Molecular Weight289.54
FormulaC12H7Cl3O2
Cas No.3380-34-5
SmilesOC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl
Relative Density.1.4214 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (189.96 mM)
Ethanol: 57 mg/mL (196.86 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM3.4538 mL17.2688 mL34.5375 mL172.6877 mL
5 mM0.6908 mL3.4538 mL6.9075 mL34.5375 mL
10 mM0.3454 mL1.7269 mL3.4538 mL17.2688 mL
20 mM0.1727 mL0.8634 mL1.7269 mL8.6344 mL
50 mM0.0691 mL0.3454 mL0.6908 mL3.4538 mL
100 mM0.0345 mL0.1727 mL0.3454 mL1.7269 mL

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