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Ibezapolstat
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Catalog No. T10243Cas No. 1275582-97-2
Alias GLS-362E, GLS362E, ACX-362E, ACX362E
Ibezapolstat (ACX-362E) is an orally active DNA polymerase IIIC inhibitor, an antibiotic with antibacterial activity that inhibits Clostridioides difficile (C. difficile) and can be used for studying Clostridioides difficile infections.
Ibezapolstat
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Purity: 98%
Catalog No. T10243Alias GLS-362E, GLS362E, ACX-362E, ACX362ECas No. 1275582-97-2
Ibezapolstat (ACX-362E) is an orally active DNA polymerase IIIC inhibitor, an antibiotic with antibacterial activity that inhibits Clostridioides difficile (C. difficile) and can be used for studying Clostridioides difficile infections.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $142 | 5 days | |
| 5 mg | $297 | In Stock | |
| 25 mg | $916 | 1-2 weeks | |
| 50 mg | $1,190 | 1-2 weeks | |
| 100 mg | $1,860 | 1-2 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ibezapolstat (ACX-362E) is an orally active DNA polymerase IIIC inhibitor, an antibiotic with antibacterial activity that inhibits Clostridioides difficile (C. difficile) and can be used for studying Clostridioides difficile infections. |
| Targets&IC50 | DNA polymerase IIIC (C. difficile):0.325 μM (Ki) |
| In vitro | Ibezapolstat (IBZ) is a competitive inhibitor of the bacterial Pol IIIC enzyme with strong in vitro activity against wild-type, susceptible strains and a MIC50/90 of 4/8μg/mL against C. difficile strains. [1] Ibezapolstat is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. difficile.[2] |
| Alias | GLS-362E, GLS362E, ACX-362E, ACX362E |
| Molecular Weight | 423.3 |
| Formula | C18H20Cl2N6O2 |
| Cas No. | 1275582-97-2 |
| Smiles | O=C1N=C(NC=2N=CN(C12)CCN3CCOCC3)NCC4=CC=C(Cl)C(Cl)=C4 |
| Relative Density. | 1.56 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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