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Tetracycline hydrochloride

🥰Excellent
Catalog No. T0912Cas No. 64-75-5
Alias Tetracycline HCl, NCI-c55561

Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.

Tetracycline hydrochloride

Tetracycline hydrochloride

🥰Excellent
Purity: 99.43%
Catalog No. T0912Alias Tetracycline HCl, NCI-c55561Cas No. 64-75-5
Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.
Pack SizePriceAvailabilityQuantity
500 mg$41In Stock
1 g$59In Stock
1 mL x 10 mM (in DMSO)$45In Stock
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Purity:99.43%
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Product Introduction

Bioactivity
Description
Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.
In vitro
Tetracyclines are versatile broad-spectrum antibiotics effective against a vast array of organisms, including gram-positive and gram-negative bacteria, as well as atypical pathogens like chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. Their mechanism of action involves blocking bacterial protein synthesis by hindering the binding of aminoacyl-tRNA to the bacterial ribosome. Specifically, in gram-negative enteric bacteria, tetracyclines enter through OmpF and OmpC porin channels as positively charged coordination complexes, likely involving magnesium ([1]).
In vivo
Tetracyclines are utilized for managing infections in various livestock, including poultry, cattle, sheep, and swine, and in aquaculture species such as salmon, catfish, and lobsters[2]. In specific scenarios, such as treating large populations of commercially farmed poultry, these antibiotics may be administered directly through feed, water, or aerosols. Additionally, tetracyclines may serve to promote or enhance growth.
AliasTetracycline HCl, NCI-c55561
Chemical Properties
Molecular Weight480.9
FormulaC22H24N2O8·HCl
Cas No.64-75-5
SmilesC[C@@]1([C@H]2C[C@H]3[C@@H](C(=C(C(=O)[C@]3(C(=C2C(=O)c2c1cccc2O)O)O)C(=O)N)O)N(C)C)O.Cl
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (93.57 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: 88 mg/mL (183 mM)
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.0794 mL10.3972 mL20.7943 mL103.9717 mL
5 mM0.4159 mL2.0794 mL4.1589 mL20.7943 mL
10 mM0.2079 mL1.0397 mL2.0794 mL10.3972 mL
20 mM0.1040 mL0.5199 mL1.0397 mL5.1986 mL
50 mM0.0416 mL0.2079 mL0.4159 mL2.0794 mL
H2O
1mg5mg10mg50mg
100 mM0.0208 mL0.1040 mL0.2079 mL1.0397 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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