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Tetracycline hydrochloride
Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.
Catalog No. T0912Cas No. 64-75-5
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Purity:99.43%
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Tetracycline hydrochloride
Catalog No. T0912Alias Tetracycline HCl, NCI-c55561Cas No. 64-75-5
Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $41 | In Stock | |
| 1 g | $59 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock |
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Doxycycline
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry. |
| In vitro | Tetracyclines are versatile broad-spectrum antibiotics effective against a vast array of organisms, including gram-positive and gram-negative bacteria, as well as atypical pathogens like chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. Their mechanism of action involves blocking bacterial protein synthesis by hindering the binding of aminoacyl-tRNA to the bacterial ribosome. Specifically, in gram-negative enteric bacteria, tetracyclines enter through OmpF and OmpC porin channels as positively charged coordination complexes, likely involving magnesium ([1]). |
| In vivo | Tetracyclines are utilized for managing infections in various livestock, including poultry, cattle, sheep, and swine, and in aquaculture species such as salmon, catfish, and lobsters[2]. In specific scenarios, such as treating large populations of commercially farmed poultry, these antibiotics may be administered directly through feed, water, or aerosols. Additionally, tetracyclines may serve to promote or enhance growth. |
| Alias | Tetracycline HCl, NCI-c55561 |
| Molecular Weight | 480.9 |
| Formula | C22H24N2O8·HCl |
| Cas No. | 64-75-5 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (93.57 mM)  Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: 88 mg/mL (183 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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