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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $36 | In Stock | |
50 mg | $52 | In Stock | |
100 mg | $81 | In Stock | |
200 mg | $123 | In Stock | |
500 mg | $189 | In Stock | |
1 mL x 10 mM (in DMSO) | $39 | In Stock |
Description | Moxifloxacin hydrochloride (BAY12-8039 HCl) is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria as well as atypical pathogens. Moxifloxacin has been linked to mild ALT elevations during therapy and to rare instances of idiosyncratic acute liver injury with symptoms and jaundice. |
In vitro | In a mouse model simulating human disease, treatment with Moxifloxacin combined with RIF (Rifampicin)/PZA (Pyrazinamide) shortened the therapy duration by two months compared to the standard regimen of INH (Isoniazid)/RIF/PZA. Similarly, biweekly administration of Rifampicin/Moxifloxacin/PZA led to stable cure after four months, whereas daily treatment with Rifampicin/INH/PZA resulted in cure after six months. |
In vivo | Moxifloxacin exhibits a broad spectrum of antibacterial activity both in vitro and clinically against various pathogens, including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, H. parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydophila pneumoniae, and Mycoplasma pneumoniae. It functions by stabilizing the DNA-drug-enzyme complex, thereby inhibiting ATP-dependent topoisomerase II (DNA gyrase) and topoisomerase IV, critical enzymes for bacterial DNA replication, transcription, repair, and recombination. |
Alias | BAY-128039, Moxifloxacin HCl, BAY12-8039 HCl |
Molecular Weight | 437.89 |
Formula | C21H25ClFN3O4 |
Cas No. | 186826-86-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 15 mg/mL(34.3 mM) DMSO: 88 mg/mL (200.96 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
DMSO
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