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Drug-induced Liver Injury (DILI) Compound Library

Catalog No. L5510
  Library Compound List   Excel SDF

Adverse drug events such as cardiotoxicity, hepatotoxicity and other organ toxicities, keep surfacing in the clinic and idiosyncratic drug toxicity continues to haunt the drug development process. Drug-induced liver injury (DILI) is common and nearly all classes of medications can cause liver disease. Although cardiotoxicity remains one of the main reasons for drug development termination, both during pre-clinical and clinical stages, DILI is the most common reason cited for withdrawal of an approved drug. The reason for this most likely lies in the fact that significant advancement in understanding the mechanistic basis of cardiotoxicity but the imperfect prediction of DILI risk.

DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural and functional integrity of the liver (e.g., mitochondrial dysfunction); production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver.

TargetMol’s Drug-induced Liver Injury Compound Library collects 1040 hepatotoxicity causing compounds, including anti-cancer drugs, antibiotics, antituberculosis agents, antiretrovirals, antiepileptic agents, and cardiac medications, etc. It is not only a powerful tool for DILI research and other drug toxicities but is of crucial value in understanding the mechanisms of DILI, identifying biomarkers for early DILI prediction, and allowing timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.

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Product Description

  • A unique collection of 1040 hepatotoxicity causing compounds, a powerful tool for drug toxicity study, can be used for HTS and HCS screening;
  • Include anti-cancer drugs, antibiotics, antituberculotic agents, antiretrovirals, antiepileptic agents, and cardiac medications, etc.;
  • Diversified in toxicities: Steatosis, Mitochondrial toxicity, cholestasis, drug allergy (hypersensitivity), etc.;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L5510)

Library Composition

Antibacterial (259)
Autophagy (200)
Antibiotic (183)
Apoptosis (151)
5-HT Receptor (54)
Endogenous Metabolite (54)
Adrenergic Receptor (52)
DNA/RNA Synthesis (52)
Dopamine Receptor (46)
AChR (45)
Parasite (43)
COX (42)
HIV Protease (42)
Histamine Receptor (35)
Potassium Channel (30)
Sodium Channel (27)
Topoisomerase (26)
P450 (25)
Ferroptosis (25)
Antifungal (24)
Mitophagy (23)
Nucleoside Antimetabolite/Analog (22)
Calcium Channel (21)
Microtubule Associated (20)
RAAS (20)
VEGFR (19)
SARS-CoV (18)
PDGFR (18)
DNA Alkylator/Crosslinker (17)
Influenza Virus (17)
Reactive Oxygen Species (17)
Reverse Transcriptase (17)
Serotonin Transporter (16)
Dehydrogenase (16)
c-Kit (16)
GABA Receptor (15)
Estrogen/progestogen Receptor (15)
Norepinephrine (13)
HDAC (13)
PDE (13)
PPAR (11)
ROS (11)
FLT (11)
ribosome (11)
HSV (11)
EGFR (11)
MRP (11)
MAO (11)
NF-κB (10)
HMG-CoA Reductase (9)
Virus Protease (9)
Antifolate (9)
Proteasome (9)
HCV Protease (9)
Antifection (8)
Opioid Receptor (8)
Estrogen Receptor/ERR (8)
DNA Alkylation (8)
Bcr-Abl (8)
ALK (8)
Androgen Receptor (8)
ADC Cytotoxin (8)
Raf (8)
Src (8)
TNF (8)
FGFR (8)
NMDAR (7)
PI3K (7)
Retinoid Receptor (7)
CDK (7)
HBV (7)
Tyrosine Kinases (7)
Phosphatase (6)
PKC (6)
Adenosine Receptor (6)
Progesterone Receptor (6)
P-gp (6)
Proton pump (6)
mTOR (6)
Glucocorticoid Receptor (6)
CaMK (6)
Carbonic Anhydrase (6)
MMP (6)
c-RET (6)
ATPase (5)
GluR (5)
DNA Methyltransferase (5)
Antiviral (5)
Trk receptor (5)
TLR (5)
DHFR (5)
MEK (5)
Chloride channel (5)
Thrombin (5)
Monoamine Oxidase (5)
iGluR (5)
Lipoxygenase (5)
P2 Receptor (4)
BTK (4)
Fatty Acid Synthase (4)
AMPK (4)
DNA (4)
TRP/TRPV Channel (4)
Glutathione Peroxidase (4)
Prostaglandin Receptor (4)
Transferase (4)
TGF-beta/Smad (4)
Antioxidant (4)
Factor Xa (4)
AChE (4)
ABC (4)
TAM Receptor (4)
Phospholipase (4)
c-Met/HGFR (4)
PARP (4)
Serine Protease (3)
JAK (3)
Syk (3)
Gamma-secretase (3)
Monoamine Transporter (3)
Xanthine Oxidase (3)
Reductase (3)
CAT (3)
DPP-4 (3)
Melatonin Receptor (3)
Histone Methyltransferase (3)
STAT (3)
Endothelin Receptor (3)
Hydroxylase (3)
HER (3)
AhR (3)
Akt (3)
Hedgehog/Smoothened (3)
Thyroid hormone receptor(THR) (3)
Interleukin (3)
Drug Metabolite (2)
Smo (2)
Rho (2)
RSV (2)
Sigma receptor (2)
S1P Receptor (2)
DNA gyrase (2)
UGT (2)
CRISPR/Cas9 (2)
Pyroptosis (2)
Telomerase (2)
Serine/threonin kinase (2)
YAP (2)
Mitochondrial Metabolism (2)
GST (2)
Leukotriene Receptor (2)
Isocitrate Dehydrogenase (IDH) (2)
MT Receptor (2)
NADPH (2)
NO Synthase (2)
IL Receptor (2)
IGF-1R (2)
Nrf2 (2)
HSP (2)
HIF/HIF Prolyl-Hydroxylase (2)
Adenosine deaminase (2)
Aminopeptidase (2)
LPL Receptor (2)
GNRH Receptor (2)
CCR (2)
CFTR (2)
BCL (2)
Beta Amyloid (2)
c-Fms (2)
FAK (2)
JNK (1)
IκB/IKK (1)
IRE1 (1)
Wnt/beta-catenin (1)
Integrin (1)
Integrase (1)
Free radical scavengers (1)
Sirtuin (1)
FXR (1)
Somatostatin (1)
VDA (1)
GPR (1)
IAP (1)
Hydrogenase (1)
Glucokinase (1)
Histone Demethylase (1)
Histone Acetyltransferase (1)
GlyT (1)
Hexokinase (1)
Lipid (1)
Guanylate cyclase (1)
Tyrosinase (1)
GSK-3 (1)
GRK (1)
Hck (1)
cholecystokinin (1)
ROR (1)
Aurora Kinase (1)
ACK (1)
DUB (1)
Annexin A (1)
Anti-infection (1)
Aromatase (1)
Aryl Hydrocarbon Receptor (1)
Beta-Secretase (1)
Epigenetic Reader Domain (1)
Caspase (1)
CaSR (1)
Decarboxylase (1)
Cysteine Protease (1)
CSF-1R (1)
CETP (1)
Ephrin Receptor (1)
PAK (1)
ROCK (1)
Neurokinin receptor (1)
LTR (1)
MAPK (1)
Mdm2 (1)
Chk (1)
Ras (1)
NADPH-oxidase (1)
NOD-like Receptor (NLR) (1)
PKA (1)
Protease-activated Receptor (1)
NPC1L1 (1)
OAT (1)
Oxytocin Receptor (1)
PLK (1)
Platelet aggregation (1)
p38 MAPK (1)
ERK (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE