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Fosmidomycin sodium salt

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Catalog No. T11315Cas No. 66508-37-0
Alias FR-31564 sodium salt

Fosmidomycin sodium salt (FR-31564 sodium salt) is an anti-infective antibiotic with anti-malarial activity that inhibits both Gram-negative and Gram-positive bacteria.

Fosmidomycin sodium salt

Fosmidomycin sodium salt

🥰Excellent
Purity: 99.18%
Catalog No. T11315Alias FR-31564 sodium saltCas No. 66508-37-0
Fosmidomycin sodium salt (FR-31564 sodium salt) is an anti-infective antibiotic with anti-malarial activity that inhibits both Gram-negative and Gram-positive bacteria.
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Purity:99.18%
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Product Introduction

Bioactivity
Description
Fosmidomycin sodium salt (FR-31564 sodium salt) is an anti-infective antibiotic with anti-malarial activity that inhibits both Gram-negative and Gram-positive bacteria.
In vitro
FR-31564 is a novel phosphonic acid antibiotic that exhibits activity against most Gram-negative and Gram-positive bacteria, except for mucoid Pseudomonas aeruginosa and glucose non-fermenting Gram-negative rods (excluding Pseudomonas aeruginosa).[1][2][3].
In vivo
After oral administration of 50 or 100 mg/kg of Fosmidomycin sodium salt, animals showed no parasites in their bodies, while treatment with 20 mg/kg resulted in a parasitemia rate of less than 1%. However, recurrence was observed when treatment was discontinued after 4 days. Complete cure was achieved in mice treated with 30 mg/kg of Fosmidomycin sodium salt 8 days.Animals apparently free of parasites are observed after intraperitoneal treatment[2].
AliasFR-31564 sodium salt
Chemical Properties
Molecular Weight205.08
FormulaC4H9NNaO5P
Cas No.66508-37-0
SmilesO=CN(CCCP([O-])(O)=O)O.[Na+]
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 20 mg/mL (97.52 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM4.8761 mL24.3807 mL48.7615 mL243.8073 mL
5 mM0.9752 mL4.8761 mL9.7523 mL48.7615 mL
10 mM0.4876 mL2.4381 mL4.8761 mL24.3807 mL
20 mM0.2438 mL1.2190 mL2.4381 mL12.1904 mL
50 mM0.0975 mL0.4876 mL0.9752 mL4.8761 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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