Fosmidomycin sodium salt (FR-31564 sodium salt) is an anti-infective antibiotic with anti-malarial activity that inhibits both Gram-negative and Gram-positive bacteria.

FR-31564 is a novel phosphonic acid antibiotic that exhibits activity against most Gram-negative and Gram-positive bacteria, except for mucoid Pseudomonas aeruginosa and glucose non-fermenting Gram-negative rods (excluding Pseudomonas aeruginosa).[1][2][3].

After oral administration of 50 or 100 mg/kg of Fosmidomycin sodium salt, animals showed no parasites in their bodies, while treatment with 20 mg/kg resulted in a parasitemia rate of less than 1%. However, recurrence was observed when treatment was discontinued after 4 days. Complete cure was achieved in mice treated with 30 mg/kg of Fosmidomycin sodium salt 8 days.Animals apparently free of parasites are observed after intraperitoneal treatment[2].