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Pafuramidine (DB289) is an experimental prodrug of the orally active metabolite DB75, a potent antiparasitic compound with anti-malarial activity used in the study of parasitic infections and sleeping sickness.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $98 | In Stock | |
5 mg | $247 | In Stock | |
10 mg | $376 | In Stock | |
25 mg | $628 | In Stock | |
50 mg | $883 | In Stock | |
1 mL x 10 mM (in DMSO) | $272 | In Stock |
Description | Pafuramidine (DB289) is an experimental prodrug of the orally active metabolite DB75, a potent antiparasitic compound with anti-malarial activity used in the study of parasitic infections and sleeping sickness. |
In vitro | The results of this investigation suggest that DB75 inhibits mitochondrial function. Yeast cells relying upon mitochondrial metabolism for energy production are especially sensitive to DB75 [1]. |
In vivo | In monkeys infected with Trypanosoma cruzi, treatment with oral Pafuramidine at doses of 1, 3 and 10 mg/kg for five consecutive days on the seventh day post-infection (p.i.) of early infection showed that Pafuramidine treatment benefited most of the monkeys, and at the end of the experiment all monkeys except group 1 had improved body weights and PCVs, and in some individuals parasitemia and cerebrospinal fluid parasitemia had cleared. [1] |
Alias | DB289, DB 289 |
Molecular Weight | 364.4 |
Formula | C20H20N4O3 |
Cas No. | 186953-56-0 |
Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 20 mg/mL(54.88 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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