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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $129 | In Stock | |
5 mg | $313 | In Stock | |
10 mg | $497 | In Stock | |
25 mg | $1,060 | In Stock | |
50 mg | $1,860 | In Stock | |
100 mg | $3,270 | In Stock |
Description | Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation. |
In vitro | Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) mitigates TGF-β1-induced α-SMA increase and inhibits histone H3K4 monomethylation upregulation in renal epithelial and fibroblast cells [2]. |
In vivo | In obstructive nephropathy, Sinefungin (10 mg/kg, per day immediately after UUO) improves renal fibrosis [2]. |
Alias | Adenosyl-Ornithine, A-9145, Antibiotic 32232RP |
Molecular Weight | 381.39 |
Formula | C15H23N7O5 |
Cas No. | 58944-73-3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 95 mg/mL (249.09 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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