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Rifalazil

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Catalog No. T16749Cas No. 129791-92-0
Alias KRM-1648, KRM1648, ABI-1648, ABI1648

Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity. It inhibits bacterial RNA polymerase, blocking the β-subunit, and is used in Chlamydia infection research.

Rifalazil

Rifalazil

🥰Excellent
Catalog No. T16749Alias KRM-1648, KRM1648, ABI-1648, ABI1648Cas No. 129791-92-0
Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity. It inhibits bacterial RNA polymerase, blocking the β-subunit, and is used in Chlamydia infection research.
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2 mg$107 In Stock
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Product Introduction

Bioactivity
Description
Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity. It inhibits bacterial RNA polymerase, blocking the β-subunit, and is used in Chlamydia infection research.
In vitro
The MIC50 values of Rifalazil were 0.0015, 0.0039 and 0.0313 μg/ml for Clostridium difficile, Clostridium perfringens and Bacteroides fragile, respectively. Rifalazi showed antibacterial activity against gram-negative gut bacteria with MIC50 values of 16 μg/ml for Escherichia coli and 16 ug/ml for Klebsiella pneumoniae. [1]
The MIC of Rifalazil against rifampicin-resistant mutants of Chlamydia pneumoniae was 0.125 μg/ml. [4]
In vivo
Treatment with Rifalazil (5 or 10 mg/kg orally for 15 weeks) improved the redness and swelling of the foot pads in mice with ulcer-infected models. [2]
Rifalazil (20 mg/kg for 5 days) can treat and prevent recurrence of Clostridium difficile-associated diarrhea in hamsters. [3]
AliasKRM-1648, KRM1648, ABI-1648, ABI1648
Chemical Properties
Molecular Weight941.07
FormulaC51H64N4O13
Cas No.129791-92-0
SmilesC[C@H]1/C=C/C=C(C)\C(NC2=C3C(N=C4C(O3)=CC(N5CCN(CC(C)C)CC5)=CC4=O)=C6C(C2=O)=C(O)C(C)=C7C6=C(O)[C@](O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@H]1O)(C)O7)=O
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4 mg/mL (4.25 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.0626 mL5.3131 mL10.6262 mL53.1310 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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