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Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity. It inhibits bacterial RNA polymerase, blocking the β-subunit, and is used in Chlamydia infection research.
Pack Size | Price | Availability | Quantity |
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2 mg | $107 | In Stock |
Description | Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity. It inhibits bacterial RNA polymerase, blocking the β-subunit, and is used in Chlamydia infection research. |
In vitro | The MIC50 values of Rifalazil were 0.0015, 0.0039 and 0.0313 μg/ml for Clostridium difficile, Clostridium perfringens and Bacteroides fragile, respectively. Rifalazi showed antibacterial activity against gram-negative gut bacteria with MIC50 values of 16 μg/ml for Escherichia coli and 16 ug/ml for Klebsiella pneumoniae. [1] The MIC of Rifalazil against rifampicin-resistant mutants of Chlamydia pneumoniae was 0.125 μg/ml. [4] |
In vivo | Treatment with Rifalazil (5 or 10 mg/kg orally for 15 weeks) improved the redness and swelling of the foot pads in mice with ulcer-infected models. [2] Rifalazil (20 mg/kg for 5 days) can treat and prevent recurrence of Clostridium difficile-associated diarrhea in hamsters. [3] |
Alias | KRM-1648, KRM1648, ABI-1648, ABI1648 |
Molecular Weight | 941.07 |
Formula | C51H64N4O13 |
Cas No. | 129791-92-0 |
Smiles | C[C@H]1/C=C/C=C(C)\C(NC2=C3C(N=C4C(O3)=CC(N5CCN(CC(C)C)CC5)=CC4=O)=C6C(C2=O)=C(O)C(C)=C7C6=C(O)[C@](O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@H]1O)(C)O7)=O |
Relative Density. | 1.31g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
Solubility Information | DMSO: 4 mg/mL (4.25 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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