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Azlocillin sodium salt

🥰Excellent
Catalog No. T0049Cas No. 37091-65-9
Alias Sodium azlocillin, Azlocillin sodium

Azlocillin sodium, an acylampicillin, is a broad-spectrum antibiotics

Azlocillin sodium salt

Azlocillin sodium salt

🥰Excellent
Purity: 97.63%
Catalog No. T0049Alias Sodium azlocillin, Azlocillin sodiumCas No. 37091-65-9
Azlocillin sodium, an acylampicillin, is a broad-spectrum antibiotics
Pack SizePriceAvailabilityQuantity
200 mg$30In Stock
500 mg$48In Stock
1 g$81In Stock
1 mL x 10 mM (in DMSO)$53In Stock
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Purity:97.63%
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Product Introduction

Bioactivity
Description
Azlocillin sodium, an acylampicillin, is a broad-spectrum antibiotics
In vitro
Azlocillin (12.5 μg/mL) inhibits over 75% of the isolates of Pseudomonas aeruginosa. Azlocillin (12.5 μg/mL) is also active against indole-negative and -positive Proteus spp., inhibiting 98 and 71%, respectively. Azlocillin is more active than mezlocillin, ticarcillin, and carbenicillin and as active as BLP-1654 against isolates of P. aeruginosa. [1] The acyl side chains of Azlocillin have an ureido-(urea) structurehence the name 'ureidopenicillins' or, more specifically, 'acylureidopenicillins.' In vitro studies against P. aeruginosa demonstrates that piperacillin has activity that is twice that of azlocillin, 4 times that of mezlocillin and ticarcillin, and about 8 times that of carbenicillin. Azlocillin produces elongated bacterial forms with delayed or no lysis in morphologic studies. [2] Azlocillin has MICs of 12.5 μg/mL on Pseudomonas aeruginosa. Azlocillin (3.125 μg/mL) results in a reduction in the rate of growth but no bactericidal phase on Pseudomonas aeruginosa. Azlocillin decreases an initial lag phase with increasing drug concentration. At the lower concentration of tobramycin (0.5 μg/ml), the combinations with both the high and the low concentrations of Azlocillin are more effective than the individual components on Pseudomonas aeruginosa. [3] Isolates with derepression of AmpC enzyme are one to two doubling dilutions more resistant to azlocillin than are those in which increased efflux or impermeability is inferred. Those with secondary β-lactamases are mostly (12/14 cases) susceptible to ceftazidime at 4 mg/L, but are amongst the most resistant to Azlocillin (MIC ≥128 mg/L in 10/14 cases). [4]
AliasSodium azlocillin, Azlocillin sodium
Chemical Properties
Molecular Weight483.47
FormulaC20H22N5NaO6S
Cas No.37091-65-9
Smiles[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c3ccccc3)C(=O)N2[C@H]1C([O-])=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (186.2 mM)
H2O: 89 mg/mL (184.1 mM)
Ethanol: 3 mg/mL (6.19 mM)
Solution Preparation Table
Ethanol/H2O/DMSO
1mg5mg10mg50mg
1 mM2.0684 mL10.3419 mL20.6838 mL103.4190 mL
5 mM0.4137 mL2.0684 mL4.1368 mL20.6838 mL
H2O/DMSO
1mg5mg10mg50mg
10 mM0.2068 mL1.0342 mL2.0684 mL10.3419 mL
20 mM0.1034 mL0.5171 mL1.0342 mL5.1710 mL
50 mM0.0414 mL0.2068 mL0.4137 mL2.0684 mL
100 mM0.0207 mL0.1034 mL0.2068 mL1.0342 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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