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Olsalazine disodium
🥰Excellent
Catalog No. T1544Cas No. 6054-98-4
Alias Olsalazine Sodium, Dipentum
Olsalazine disodium (Dipentum) is bioconverted to 5-aminosalicylic acid (5-ASA) in the colon and has anti-inflammatory activity in ulcerative colitis.
Olsalazine disodium
🥰Excellent
Purity: 99.52%
Catalog No. T1544Alias Olsalazine Sodium, DipentumCas No. 6054-98-4
Olsalazine disodium (Dipentum) is bioconverted to 5-aminosalicylic acid (5-ASA) in the colon and has anti-inflammatory activity in ulcerative colitis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $45 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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CitedSelect Batch
Purity:99.52%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Olsalazine disodium (Dipentum) is bioconverted to 5-aminosalicylic acid (5-ASA) in the colon and has anti-inflammatory activity in ulcerative colitis. |
| Targets&IC50 | Chemotaxis to LTB4 (human intestinal macrophages):0.39 mM |
| In vitro | In nu/nu CD-1 mice with experimental colitis induced by sodium dextran sulfate, daily treatment with Olsalazine (50 mg/kg) led to the bacterial azoreductase cleavage of azo bonds, releasing mesalazine, which is capable of treating colitis. |
| In vivo | In isolated rat ileal and guinea pig ileal mucosa, Olsalazine (less than 2.89 mM) increases the secretion of sodium and chloride ions, while decreasing the absorption of chloride ions. In isolated rat colonic tissues, Olsalazine (less than 11.5 mM) reduces net sodium levels and chloride ion absorption in a dose-dependent manner, and at high concentrations (11.5 mM), it increases potassium secretion. Moreover, in isolated rat jejunum, Olsalazine inhibits the absorption of glucose and lactose. In human intestinal macrophages (IC50=0.39 mM), Olsalazine acts as an effective inhibitor of the chemotaxis of LTB4. |
| Alias | Olsalazine Sodium, Dipentum |
| Molecular Weight | 346.2 |
| Formula | C14H8N2Na2O6 |
| Cas No. | 6054-98-4 |
| Smiles | [Na+].[Na+].Oc1ccc(cc1C([O-])=O)\N=N\c1ccc(O)c(c1)C([O-])=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 38 mg/mL (109.8 mM) DMSO: 50 mg/mL (144.43 mM)  Ethanol: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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