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Olsalazine disodium

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Purity:99.86%

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COA HNMR HPLC

Olsalazine disodium

Catalog No. T1544Cas No. 6054-98-4

Olsalazine disodium (Dipentum) is bioconverted to 5-aminosalicylic acid (5-ASA) in the colon and has anti-inflammatory activity in ulcerative colitis.

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Pack Size	Price	Availability	Quantity
500 mg	$45	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Olsalazine disodium (Dipentum) is bioconverted to 5-aminosalicylic acid (5-ASA) in the colon and has anti-inflammatory activity in ulcerative colitis.
In vitro	In nu/nu CD-1 mice with experimental colitis induced by sodium dextran sulfate, daily treatment with Olsalazine (50 mg/kg) led to the bacterial azoreductase cleavage of azo bonds, releasing mesalazine, which is capable of treating colitis.
In vivo	In isolated rat ileal and guinea pig ileal mucosa, Olsalazine (less than 2.89 mM) increases the secretion of sodium and chloride ions, while decreasing the absorption of chloride ions. In isolated rat colonic tissues, Olsalazine (less than 11.5 mM) reduces net sodium levels and chloride ion absorption in a dose-dependent manner, and at high concentrations (11.5 mM), it increases potassium secretion. Moreover, in isolated rat jejunum, Olsalazine inhibits the absorption of glucose and lactose. In human intestinal macrophages (IC50=0.39 mM), Olsalazine acts as an effective inhibitor of the chemotaxis of LTB4.
Alias	Dipentum, Olsalazine Sodium

Chemical Properties

Molecular Weight	346.2
Formula	C14H8N2Na2O6
Cas No.	6054-98-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 38 mg/mL (109.8 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (144.43 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8885 mL	14.4425 mL	28.8850 mL	144.4252 mL
5 mM	0.5777 mL	2.8885 mL	5.7770 mL	28.8850 mL
10 mM	0.2889 mL	1.4443 mL	2.8885 mL	14.4425 mL
20 mM	0.1444 mL	0.7221 mL	1.4443 mL	7.2213 mL
50 mM	0.0578 mL	0.2889 mL	0.5777 mL	2.8885 mL
100 mM	0.0289 mL	0.1444 mL	0.2889 mL	1.4443 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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