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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | Backorder | |
500 mg | Inquiry | Backorder |
Description | JH-LPH-28, a sulfonyl piperazine analog, is a potent inhibitor of UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH, exhibiting exceptional antibiotic activity with a minimum inhibitory concentration (MIC) of 0.83 μg/mL. |
In vitro | JH-LPH-28 effectively suppresses bacterial growth with a concentration as low as 2.8 μg/mL and demonstrates a Minimum Inhibitory Concentration (MIC) of 1.6 μg/mL against wild-type K. pneumoniae. Additionally, it exhibits IC50 values of 0.11 μM against K. pneumoniae LpxH and 0.083 μM against E. coli LpxH, indicating strong inhibitory activity against these bacterial enzymes. |
Cas No. | 2414592-36-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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