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TargetMol | Compound Library

Target-Focused Phenotypic Screening Library

Catalog No. L9500

TargetMol offers a high quality Target-focused Phenotypic Screening Library (1796 compounds in total) with maximal biological and chemical diversity for such empirical approaches. Phenotypic approaches use semi-empirical methods that do not require much knowledge of the target and understanding of the mechanism. A recent analysis revealed the phenotypic approaches to be the more successful strategy for small-molecule, first-in-class medicines. The rationalization for this success was the unbiased identification of the molecular mechanism of action (MMOA). In addition, an understanding of mechanism is not required for regulatory approval; the regulatory agencies are less concerned with the MMOA of a compound than with whether it is effective. It can be argued that in seeking the best path to new medicines, academic science should be focusing not on gene-based, hypothesis-driven research but on translating disease knowledge into disease-relevant phenotypic assays for screening and chemical biology approaches to screening and target identification as well as on systematic approaches to understanding the MMOA. Greater focus on translational research should lead to greater access to more reliable phenotypic assays. Use of well-annotated bioactive compounds with clear targets for phenotypic screening can also narrow the scope of targets that are needed to be validated, therefore, it is an effective tool for target identification or validation. Given the potential applications of a Phenotypic Screening Library, the focus of the compounds selection strategy lies on biodiversity and maximal coverage of chemical space, aimed at providing hits for a wide spectrum of biological goals. This library finally was developed to contain a set of compounds with confirmed biological activity for more than 600 drug targets and includes 2-4 structurally diverse compounds for each target.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L9500

Target-Focused Phenotypic Screening Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 1796 annotated bioactive compounds with clear targets, suitable for phenotypic screening;
  • Cover more than 600 drug targets, Structurally diverse;
  • 2-4 structurally diversified compounds for the same annotated 'on-target' to increase the success rate of target identification (enables the generation of much stronger target–phenotype hypotheses);
  • Detailed information about compound structure, target, activity, etc.;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

Apoptosis
Autophagy
Antibacterial
Endogenous Metabolite
5-HT Receptor
Antibiotic
AChR
Adrenergic Receptor
DNA/RNA Synthesis
VEGFR
Cytochromes P450
Dopamine Receptor
HIV Protease
PI3K
Epigenetic Reader Domain
PDE
Histamine Receptor
FGFR
PDGFR
COX
Influenza Virus
CDK
Ferroptosis
Parasite
TRP/TRPV Channel
NF-κB
FLT
c-Kit
Src
Potassium Channel
EGFR
Raf
GluR
Histone Methyltransferase
HCV Protease
PPAR
Calcium Channel
Dehydrogenase
JAK
TGF-beta/Smad
Mitophagy
Reactive Oxygen Species
HDAC
Topoisomerase
SARS-CoV
c-Met/HGFR
Adenosine Receptor
Bcr-Abl
mTOR
Bcl-2 Family
Microtubule Associated
Estrogen/progestogen Receptor
GABA Receptor
p38 MAPK
PKC
MAO
Beta Amyloid
Antifungal
RAAS
IL Receptor
ALK
IκB/IKK
GPR
Proteasome
Carbonic Anhydrase
E1/E2/E3 Enzyme
MMP
Retinoid Receptor
TNF
Sodium Channel
GSK-3
Estrogen Receptor/ERR
Prostaglandin Receptor
STAT
Monoamine Oxidase
ROR
Virus Protease
Wnt/beta-catenin
ERK
Gamma-secretase
Opioid Receptor
Aurora Kinase
Akt
HIF/HIF Prolyl-Hydroxylase
ATPase
DNA Alkylator/Crosslinker
NADPH
Phosphatase
HSV
CXCR
Interleukin
c-RET
PKA
PARP
Nucleoside Antimetabolite/Analog
Caspase
iGluR
NMDAR
DNA Alkylation
Hedgehog/Smoothened
Lipoxygenase
HSP
Trk receptor
Sirtuin
MEK
JNK
Serine Protease
ROCK
Glucocorticoid Receptor
Chk
DUB
Indoleamine 2,3-Dioxygenase (IDO)
Nrf2
Casein Kinase
ribosome
HIF
DNA Methyltransferase
S1P Receptor
LPL Receptor
P2Y Receptor
Serotonin Transporter
Serine/threonin kinase
Cholinesterase (ChE)
Norepinephrine
CaMK
SGLT
P-gp
ATM/ATR
Reverse Transcriptase
AMPK
Phospholipase
Cannabinoid Receptor
Transferase
DNA-PK
Cysteine Protease
Endothelin Receptor
TLR
c-Fms
PLK
Syk
S6 Kinase
CFTR
p53
HER
Proton pump
Monocarboxylate transporter
Reductase
HBV
Glucokinase
Drug Metabolite
Smo
CCR
HMG-CoA Reductase
Ras
TAM Receptor
Thyroid hormone receptor(THR)
Mdm2
NOS
Lipase
Tyrosine Kinases
Rho
Aryl Hydrocarbon Receptor
Mitochondrial Metabolism
BTK
ROS
OX Receptor
Acyltransferase
Histone Acetyltransferase
Aromatase
PDK
NOD
Sigma receptor
FAK
PKM
Chloride channel
DHFR
PERK
Glutathione Peroxidase
FXR
NAMPT
IDO
Phosphorylase
DNA gyrase
DPP-4
PAK
FAAH
IGF-1R
Androgen Receptor
Telomerase
ATP Citrate Lyase
MAPK
LRRK2
AhR
PD-1/PD-L1
Kinesin
BACE
Histone Demethylase
Tie-2
Factor Xa
Progesterone Receptor
Melatonin Receptor
CaSR
MRP
CSF-1R
IRE1
Annexin A
RIP kinase
ABC Transporter
Glucosidase
Monoamine Transporter
Fatty Acid Synthase
Xanthine Oxidase
cAMP
DNA
PGE Synthase
MNK
Porcupine
GPCR19
Ephrin Receptor
transporter
PAI-1
Acetyl-CoA Carboxylase
BMI-1
Tyrosinase
p97
NOD-like Receptor (NLR)
NO Synthase
Advanced Glycation End Products
DprE1
LTR
Na+/Ca2+ Exchanger
CETP
c-Myc
GNRH Receptor
Pim
Liver X Receptor
Leukotriene Receptor
LIM Kinase
UGT
P2X Receptor
ACK1
PTEN
Lipid
Survivin
STING
Free radical scavengers
RSV
Neprilysin
Hydroxylase
Neurokinin receptor
IRAK
PROTACs
Integrin
Ligands for Target Protein for PROTAC
YAP
Antioxidant
IFNAR
DYRK
Cell wall
Antifolate
Vitamin
Myosin
PAFR
MTH1
LDL
GRK
MT Receptor
GlyT
Antifection
Stearoyl-CoA Desaturase (SCD)
PGC-1α
Vasopressin Receptor
Wee1
BCRP
Beta-Secretase
Antiviral
GluCls
Pyroptosis
Carboxypeptidase
Kras
LPA Receptor
PI4K
CRISPR/Cas9
Gap Junction Protein
NADPH-oxidase
Thrombin
Protease-activated Receptor
MLK
Adenylyl Cyclase
Amino Acids and Derivatives
Arginase
VDA
OCT
Hck
IAP
SIK
Na-K-Cl cotransporter
Molecular Glues
HCN Channel
Neuropeptide Y Receptor
PAD
Aminopeptidase
ASK
Hippo pathway
GST
GPX
Ligand for E3 Ligase
Adenosine Deaminase
SGK
Discoidin Domain Receptor (DDR)
Anti-infection
Lysosomal Autophagy
ROS Kinase

Keywords