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Sulfamerazine (RP2632) is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for the binding site on dihydropteroate synthase.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
200 mg | $37 | In Stock | |
500 mg | $58 | In Stock | |
1 g | $97 | In Stock | |
5 g | $394 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Sulfamerazine (RP2632) is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for the binding site on dihydropteroate synthase. |
In vitro | Sulfamerazine significantly affects the lifespan of rats, markedly prolonging the life of male hamsters. The maximum body weight of all rats fed with sulfamerazine exceeded that of the control group. After oral administration of sulfamerazine, significant alterations in the shape of the concentration-time curve due to age were observed, strongly indicating absorption deficiencies within the first week after birth in lambs. |
In vivo | Sulfamerazine exhibits a bi-exponential decay in water and a tri-exponential decay in cyclodextrin (CD) solutions. The resonance of aromatic protons in Sulfamerazine indicates a significant upfield shift, suggesting that the aniline ring is deeply encapsulated within the CD cavity. |
Alias | RP2632 |
Molecular Weight | 264.3 |
Formula | C11H12N4O2S |
Cas No. | 127-79-7 |
Smiles | CC1=NC(NS(=O)(=O)C2=CC=C(N)C=C2)=NC=C1 |
Relative Density. | 1.439 g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (227.01 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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