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Colistin sulfate

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Purity:98%

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COA HNMR

Colistin sulfate

Catalog No. T1245Cas No. 1264-72-8

Colistin sulfate (Colistin sulfate (1066-17-7 free base)) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2.

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Pack Size	Price	Availability	Quantity
100 mg	$48	In Stock
500 mg	$81	In Stock

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Product Introduction

Bioactivity

Description	Colistin sulfate (Colistin sulfate (1066-17-7 free base)) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2.
In vitro	In mice, daily intramuscular injections of Colistin sulfate (15 mg/kg) result in granular degeneration in renal and hepatic epithelial tissues. Similarly, in piglets, daily intramuscular injections of Colistin sulfate (15 mg/kg) lead to significant neurotoxic effects.
In vivo	Colistin (2 μg/mL) exhibits broad-spectrum antibacterial activity, effectively inhibiting most strains of Escherichia coli and Pseudomonas aeruginosa, as well as all strains of the genera Enterobacter, Salmonella, Shigella, Pasteurella, Brucella, and Bordetella. Additionally, it is active against strains of the genera Moraxella, Serratia, and Providencia. In 225 strains of P. aeruginosa, the MIC90 and MIC50 of Colistin are 6.3 μg/mL and 1.6 μg/mL, respectively. In Acinetobacter baumannii, Colistin sulfate demonstrates concentration-dependent post-antibiotic effects.
Alias	Colistin sulfate (1066-17-7 free base), Polymixin E Sulfate, Polymyxin E Sulfate

Chemical Properties

Molecular Weight	1253.51
Formula	C53H100N16O17S
Cas No.	1264-72-8

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
10 mM	0.0798 mL	0.3989 mL	0.7978 mL	3.9888 mL
20 mM	0.0399 mL	0.1994 mL	0.3989 mL	1.9944 mL
50 mM	0.0160 mL	0.0798 mL	0.1596 mL	0.7978 mL
100 mM	0.0080 mL	0.0399 mL	0.0798 mL	0.3989 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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