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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $228 | In Stock | |
5 mg | $572 | In Stock | |
10 mg | $822 | In Stock | |
25 mg | $1,250 | In Stock | |
50 mg | Inquiry | In Stock |
Description | Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks. |
In vitro | PF-06647263 (anti-EFNA4-ADC) is generated via conjugation of hE22 lysine residues to the AcButDMH-N-Ac-calicheamicin-γ1 linker-payload with an average drug-to-antibody ratio (DAR) of 4.6. PF-06647263 elicits antigen- and concentration-dependent cytotoxicity, as exposure to PF-06647263 for 96 hours results in cell death (EC50: ~1 ng/mL) [1]. |
In vivo | PF-06647263 (0.27, 0.36 mg/kg) significantly induces tumor regression in TNBC xenografts. An ADC, which is a conjugate of a humanized anti-EFNA4 monoclonal antibody and the DNA-damaging agent calicheamicin, demonstrates sustained tumor regressions in TNBC and ovarian cancer PDX models in vivo [1]. |
Alias | Calicheamicin γ1 |
Molecular Weight | 1368.35 |
Formula | C55H74IN3O21S4 |
Cas No. | 108212-75-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (73.08 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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