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Maytansinol

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Purity:99.03%

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COA HPLC MS HNMR

Maytansinol

Catalog No. T16016Cas No. 57103-68-1

Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and causes microtubule disassembly in vitro.

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Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$64	In Stock
10 mg	$98	In Stock
25 mg	$198	In Stock
50 mg	$328	In Stock
100 mg	$496	In Stock
200 mg	$693	In Stock
500 mg	$1,070	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock

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Product Introduction

Bioactivity

Description	Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and causes microtubule disassembly in vitro.
In vitro	Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol causes apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to the drug. Maytansinol decreases the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses.
Alias	Ansamitocin P-0

Chemical Properties

Molecular Weight	565.05
Formula	C28H37ClN2O8
Cas No.	57103-68-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 35 mg/mL (61.94 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7698 mL	8.8488 mL	17.6975 mL	88.4877 mL
5 mM	0.3540 mL	1.7698 mL	3.5395 mL	17.6975 mL
10 mM	0.1770 mL	0.8849 mL	1.7698 mL	8.8488 mL
20 mM	0.0885 mL	0.4424 mL	0.8849 mL	4.4244 mL
50 mM	0.0354 mL	0.1770 mL	0.3540 mL	1.7698 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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