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Microtubule-Targeted Compound Library

Catalog No. L1110
  Library Compound List   Excel SDF

Microtubules (MTs) are cylindrical polymers of α- and β-tubulin heterodimers. These polymers are highly dynamic and their polymerization dynamics is tightly regulated through the binding of microtubule-associated proteins (MAPs). Microtubule polymerization and depolymerization dynamic drive chromosome congression and spindle formation during cell division, which are used to pull eukaryotic chromosomes apart. Microtubules are very important in a number of cellular processes, such as maintaining the structure of the cell, cell division, signaling transduction, transportation, etc.

Microtubules have long been considered an ideal target for anticancer drugs because of the essential role they play in mitosis, forming the dynamic spindle apparatus. Microtubule-targeting anticancer drugs are among the most effective anticancer therapeutics used in the clinic today.  Microtubule-targeting agents act primarily by altering MT dynamics. This interference with microtubule dynamics can have the effect of stopping a cell's cell cycle and can lead to programmed cell death or apoptosis. They are roughly classified into microtubule-stabilizing agents, such as taxanes (paclitaxel) or epothilones. They block dynamic instability by stabilizing GDP-bound tubulin in the microtubule to inhibit the mitosis and induce apoptosis; microtubule-destabilizing agents, such as vinca alkaloids, Nocodazole, combretastatin, and colchicine. 

TargetMol’s Microtubule-targeted Compound Library collects 155 compounds targeting microtubules that can be used in microtubule-related mechanism study and drug development.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
Request Library
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Product Description

  • A unique collection of 155 microtubule-targeted compounds can be used in HTS and HCS;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files
Request Library Compound List (L1110)

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..
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Library Composition

Microtubule Associated (129)
Apoptosis (35)
Parasite (10)
Autophagy (9)
Antibiotic (4)
Src (4)
Reactive Oxygen Species (3)
Beta Amyloid (3)
NO Synthase (3)
Kinesin (3)
HDAC (3)
Guanylate cyclase (2)
mTOR (2)
Hedgehog/Smoothened (2)
Akt (2)
Endogenous Metabolite (2)
Monoamine Oxidase (2)
ALK (2)
GSK-3 (2)
Antifungal (2)
CRISPR/Cas9 (1)
NF-κB (1)
HIF (1)
AChR (1)
Ras (1)
HIF/HIF Prolyl-Hydroxylase (1)
FGFR (1)
HIV Protease (1)
Sirtuin (1)
ATPase (1)
BCL (1)
Mitochondrial Metabolism (1)
Gamma-secretase (1)
Bcr-Abl (1)
Topoisomerase (1)
ERK (1)
Glucokinase (1)
GTPase (1)
JNK (1)
DYRK (1)
p38 MAPK (1)
Dynamin (1)
PROTACs (1)
Fatty Acid Synthase (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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