APC

Apcin is a potent and competitive inhibitor of anaphase-promoting complex cyclosome (APC C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blockin

TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress ROS JNK signaling in colon cancer cells.

TASIN-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC).

TAME hydrochloride (Tos-Arg-OMe HCl) is a kind od amino acid derivatives.

TAME (Tosyl-Arginine Methyl Este), an inhibitor of the late-promoting complex (APC C or APC), inhibits APC-dependent protein hydrolysis by competing for APC binding with the C-terminal isoleucine-arginine tail of the APC activator cytokinesis cycle 20 (Cdc20). TAME binds to and prevents APC binding by Cdc20 and Cdh20. TAME binds to APC and prevents its activation by Cdc20 and Cdh1.

Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V (HY-130

Activated Protein C (390-404), human acetate (Activated Protein C ) inhibits APC anticoagulant activity.

CFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosis, with an IC50 in the range of 10-15 μM.CFM 4 inhibits the growth of drug-resistant human breast cancer cells.

TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.