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PROTAC-Linker Conjugates for PAC
PROTAC-Antibody Conjugates (PACs) are an innovative class of therapeutic agents that combine the specificity of antibodies with the protein-degrading capabilities of PROTACs (Proteolysis-Targeting Chimeras). This combination allows for the targeted degradation of disease-causing proteins, offering a promising approach for treating various diseases, including cancer and autoimmune disorders.
PROTAC BRD4 degrader for PAC-1
T18603
PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective proteolysis of PAC-1.
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MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885
T877082722697-86-9
MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 (Comp Ie) serves as a neodegrader conjugate instrumental in the synthesis of antibody neoDegrader conjugate (AnDC) [1].
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