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Chromatin/Epigenetic Chromatin/EpigeneticMethionine Adenosyltransferase (MAT)
S-Adenosylmethionine synthetase, also known as methionine adenosyltransferase (MAT), is an enzyme that creates S-adenosylmethionine (also known as AdoMet, SAM or SAMe) by reacting methionine (a non-polar amino acid) and ATP (the basic currency of energy).
AG-270
T90502201056-66-6In house
AG-270 is an allosteric and orally active inhibitor of MAT2A.
- $112
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QTY
PF-9366
T519172882-78-1In house
PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor with an IC50 of 420 nM and a Kd of 170 nM.
- $53
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QTY
MAT2A inhibitor 2
T1195013299-99-5
MAT2A inhibitor 2 is an inhibitor of methionine adenosyltransferase 2A (MAT2A).
- $47
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QTY
AGI-25696
T102592201066-35-3In house
AGI-25696 is an inhibitor of methionine adenosyltransferase 2A (MATA2). AGI-25696 blocks the growth of MTAP-deleted tumors in vivo and can be used for studies about the treatment of cancer.
- $1,520
Size
QTY
MAT2A inhibitor 4
T92621391934-91-0
MAT2A inhibitor 4 is an inhibitor of the catalytic subunit of methionine S-adenosyltransferase-2, which is used in cancer research.
- $48
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QTY
FIDAS-3
T112841266684-01-8
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for MAT2A binding.
- $33
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MAT2A-IN-9
T731402439277-80-0
MAT2A-IN-9, a 2-oxoquinazoline derivative, is a potent MAT2A (methionine adenylyltransferase 2A) inhibitor.MAT2A-IN-9 has antitumor activity for the treatment of lymphomas and solid tumors.
- $123
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MAT2A-IN-10
T789462924825-23-8
MAT2A-IN-10 (Compound 28), an orally active inhibitor of MAT2A, exhibits an IC50 of 26 nM and is utilized in cancer research [1].
- $1,370
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QTY
MAT2A-IN-12
T79350631897-75-1
MAT2A Allosteric Inhibitor 2 is a potent, selective inhibitor exhibiting an IC50 of 5 nM and demonstrates nanomolar efficacy (IC50 = 5 μM) in proliferation assays utilizing the MTAP -/- cell line [1].
- $1,520
Size
QTY
MAT2A-IN-11
T79349
MAT2A Allosteric Inhibitor 1, also known as Compound 5, is a selective inhibitor of methionine adenosyltransferase (MAT) demonstrating potent activity with an IC50 value of 6.8 nM [1].
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