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CD ProteinsMyeloid Cell CD Proteins
Myeloid cells include dendritic cells, monocytes, macrophages, and granulocytes. A dendritic cell (DC) is an antigen-presenting cell of the mammalian immune system. A DC's main function is to process antigen material and present it on the cell surface to the T cells of the immune system. Monocytes are derived from myeloid progenitor cells in the bone marrow. There are three distinct subpopulations of human monocytes: classical, intermediate, and non-classical. Human peripheral blood mononuclear cells are defined based on the expression of cell surface antigens (CD14, CD16, and CD64) and chemokine receptors (CD192 (CCR2) and CX3CR1). Monocytes express leukocyte adhesion molecule (CD226), and the interaction between CD antigen and CD155 regulates monocyte migration. Monocytes play a key role in clearing invading bacteria, viruses, fungi and protozoa, and negatively affect the pathogenesis of inflammatory and degenerative diseases. Macrophages are a type of white blood cell of the innate immune system that engulf and digest pathogens, such as cancer cells, microbes, cellular debris, and foreign substances.They can be identified by their specific expression of proteins such as CD14, CD40, CD11b, CD64, F4/80 (mice)/EMR1 (human), lysozyme M, MAC-1/MAC-3 and CD68.
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc)
TMPY-02726
RANKL TNFSF11 CD254 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56 kDa and the accession number is AAC40113.1.
- $235
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RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)
TMPJ-00607
RANKL TNFSF11 CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1.
- $118
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CSF3R/G-CSFR Protein, Human, Recombinant (His)
TMPY-02312
CSF3R G-CSFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68 kDa and the accession number is Q99062-1.
- $310
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PD-L1 Protein, Human, Recombinant
TMPY-05208
PD-L1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.2 kDa and the accession number is Q9NZQ7-1.
- $451
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CD36 Protein, Rat, Recombinant (His)
TMPY-03243
CD36 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.8 kDa and the accession number is Q66HI4.
- $600
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CD73 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-06907
CD73 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 61.04 kDa and the accession number is NP_002517.1.
- $600
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L1CAM Protein, Mouse, Recombinant (His)
TMPK-00811
L1 cell adhesion molecule (L1CAM) is one of the first neural adhesion molecules described with important functions in the development of the nervous system. Subsequent work discovered that L1CAM is expressed in many human cancers and is often associated with bad prognosis. This is most likely due to the motility and invasion promoting function of L1CAM. L1CAM is a valuable diagnostic prognostic marker and an attractive target for the therapy of several human cancers.
- $418
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IL-4R Protein, Human, Recombinant (His)
TMPY-01055
IL-4R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.18 kDa and the accession number is P24394-1.
- $451
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BAFF/TNFSF13B Trimer Protein, Human, Recombinant (His & Flag)
TMPK-00176
B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene.BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B TACI, TNFRSF17 BCMA, and TNFRSF13C BAFF-R. BAFF TNFSF13B Trimer Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight is 52.4 kDa and the accession number is Q9Y275-1.
- $511
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RANKL/TNFSF11/CD254 Protein, Human, Recombinant
TMPY-03364
RANKL TNFSF11 CD254 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 20.5 kDa and the accession number is AAC51762.1.
- $296
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ICAM-1/CD54 Protein, Human, Recombinant (His)
TMPY-01142
ICAM-1 CD54 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51 kDa and the accession number is A0A384MEK5.
- $351
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CD155/PVR Protein, Mouse, Recombinant (mFc)
TMPY-05791
CD155 PVR Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 60.78 kDa and the accession number is Q8K094.
- $357
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RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc)
TMPY-03527
RANKL TNFSF11 CD254 Protein, Human, Recombinant (aa 63-244, rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 47.9 kDa and the accession number is O14788-2.
- $618
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TREM-2 Protein, Mouse, Recombinant (His)
TMPY-01703
TREM-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is Q99NH8-1.
- $386
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Aminopeptidase N/CD13 Protein, Human, Recombinant (I603M, His)
TMPY-00665
Aminopeptidase N CD13 Protein, Human, Recombinant (I603M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 104.2 kDa and the accession number is A0A024RC61.
- $386
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Coagulation Factor III/Tissue Factor Protein, Canine, Recombinant (His)
TMPK-00993
Tissue factor (also named Coagulation Factor III) is a cell surface glycoprotein responsible for initiating the extrinsic pathway of coagulation.Tissue factor is the primary cellular initiator of blood coagulation via interaction with coagulation factor VII. Aberrant expression of tissue factor is responsible for thrombosis during septic shock, atherosclerosis and cancer.
- $487
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CD155/PVR Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
TMPY-05597
CD155 PVR Protein, Mouse, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 62.9 kDa and the accession number is Q8K094.
- $462
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PD-1 Protein, Human, Recombinant (hFc)
TMPY-04898
PD-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession number is A0A0M3M0G7.
- $172
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PSGL-1/CD162 Protein, Human, Recombinant (His)
TMPY-03531
PSGL-1 CD162 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.5 kDa and the accession number is Q14242-1.
- $386
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CD163 Protein, Human, Recombinant (His & Avi)
TMPK-01074
The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages is a characteristic of tissues responding to inflammation. CD163 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 111.4 kDa and the accession number is Q86VB7-1.
- $465
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CD73 Protein, Mouse, Recombinant (His)
TMPY-01342
CD73 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.4 kDa and the accession number is Q0VEE0.
- $228
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CD40 Ligand Protein, Human, Recombinant (hFc)
TMPY-02022
CD40 Ligand Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.8 kDa and the accession number is P29965.
- $197
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BAFF/TNFSF13B Protein, Mouse, Recombinant (mFc)
TMPJ-01391
BAFF TNFSF13B Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predicted molecular weight is 45-60 KDa and the accession number is Q9WU72.
- $56
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RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
TMPJ-00662
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
- $118
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CD155/PVR Protein, Human, Recombinant (hFc)
TMPY-00699
CD155 PVR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.8 kDa and the accession number is P15151-1.
- $249
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CD28 Protein, Human/Cynomolgus, Recombinant (His)
TMPJ-00103
CD28 Protein, Human Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is P10747.
- $56
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PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00181
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28 CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
- $355
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4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (hFc)
TMPJ-00145
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9 4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
- $110
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RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)
TMPJ-01472
RANKL TNFSF11 CD254 Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 23-29 KDa and the accession number is O35235-1.
- $260
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DPP4/CD26 Protein, Human, Recombinant
TMPY-00779
DPP4 CD26 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 85.4 kDa and the accession number is P27487.
- $451
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LILRB1/CD85j/ILT2 Protein, Human, Recombinant (hFc)
TMPY-04781
LILRB1 CD85j ILT2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.9 kDa and the accession number is D9IDM8.
- $228
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CD73 Protein, Human, Recombinant (His)
TMPY-01851
CD73 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is P21589-1.
- $416
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CD40 Ligand Protein, Rat, Recombinant (hFc)
TMPY-03301
CD40 Ligand Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is Q9Z2V2.
- $462
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OX40L/TNFSF4 Protein, Human, Recombinant (His)
TMPJ-00064
Tumor necrosis factor ligand superfamily member 4(TNFSF4 OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells, T cells, dendritic cells and endothelial cells. OX40L binds to OX40 (CD134), a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proliferation and cytokine production. Additional, it has been found association with systemic lupus erythematosus, no association with occurrence of atherosclerosis.
- $184
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DPP4/CD26 Protein, Mouse, Recombinant (hFc)
TMPY-00221
DPP4 CD26 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 112.9 kDa and the accession number is P28843.
- $221
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TREM-2 Protein, Human, Recombinant (His)
TMPY-01148
TREM-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.9 kDa and the accession number is Q5TCX1.
- $386
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CD16a Protein, Human, Recombinant (F176V, His)
TMPY-01964
The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes macrophages, natural killer (NK) cells, and a subset of T cells._x000D_ CD16a FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a FCGR3A also has a broader function. CD16a FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.
- $386
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CD16a Protein, Rat, Recombinant (His)
TMPY-02018
CD16a Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.7 kDa and the accession number is A0A8L2QKY4.
- $386
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CD48 Protein, Human, Recombinant (hFc)
TMPY-03947
CD48 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is P09326-1.
- $386
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CD93/C1qR1 Protein, Mouse, Recombinant (hFc)
TMPY-06844
CD93 C1qR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.83 kDa and the accession number is NP_034870.1.
- $600
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CD14 Protein, Human, Recombinant (His)
TMPY-02698
CD14 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P08571.
- $228
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PD-1 Protein, Mouse, Recombinant (hFc)
TMPY-05395
PD-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.9 kDa and the accession number is Q02242.
- $113
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BAFF/TNFSF13B Protein, Human, Recombinant (His)
TMPJ-00178
BAFF TNFSF13B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 22 KDa and the accession number is Q9Y275.
- $134
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DPP4/CD26 Protein, Human, Recombinant (His)
TMPY-00122
DPP4 CD26 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.3 kDa and the accession number is P27487.
- $166
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RANK/TNFRSF11A Protein, Mouse, Recombinant (His)
TMPJ-00674
Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11 RANKL TRANCE OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, brain and kidney, but weakly expressed in spleen and bone marrow. After binding its ligand RANKL, RANK can activate signaling pathways such as NF-κB, JNK, ERK, p38, and Akt PKB, through TRAF protein phosphorylation. RANK TNFRSF11A signaling is largely considered to be growth promoting and apoptosis reducing such as the effects observed in osteoclasts. RANK TNFRSF11A was also found to be involved in the regulation of interactions between T-cells and dendritic cells.
- $116
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IL-4R Protein, Cynomolgus, Recombinant (hFc)
TMPY-05739
IL-4R Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.48 kDa and the accession number is G7Q0S7.
- $498
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PSGL-1/CD162 Protein, Human, Recombinant (mFc)
TMPY-05013
PSGL-1 CD162 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 55.4 kDa and the accession number is AAC50061.1.
- $228
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CTLA-4 Protein, Human, Recombinant (rFc)
TMPY-04998
CTLA-4 Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 39.7 kDa and the accession number is P16410-1.
- $498
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