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OX40/TNFRSF4 Protein, Mouse, Recombinant

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OX40/TNFRSF4 Protein, Mouse, Recombinant

Catalog No. TMPY-05020

OX40/TNFRSF4 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.1 kDa and the accession number is B1ASL3.

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Pack Size	Price	Availability	Quantity
200 μg	$1,000	7-10 days

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Biological Description

Biological Information	Testing in progress
Description	OX40/TNFRSF4 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.1 kDa and the accession number is B1ASL3.
Species	Mouse
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	B1ASL3
Synonyms	ACT35,CD134,Ox40,tumor necrosis factor receptor superfamily, member 4,Ly-70,TXGP1L,Txgp1
Construction	The Mouse Tnfrsf4 (NP_035789.1) (Met1-Pro211) was expressed with six amino acids (LEVLFQ) at the C-terminus.
Protein Purity	> 95 % as determined by SDS-PAGE.
Molecular Weight	22.1 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy