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CD ProteinsT Cell CD Proteins
T cells are one of the important types of white blood cells of the immune system and play a central role in the adaptive immune response. T cells are born from hematopoietic stem cells, found in the bone marrow. Developing T cells then migrate to the thymus gland to develop (or mature).After migration to the thymus, the precursor cells mature into several distinct types of T cells. T cell differentiation also continues after they have left the thymus.CD4 and CD8 T cells are selected in the thymus, but undergo further differentiation in the periphery to specialized cells which have different functions. Groups of specific, differentiated T cell subtypes have a variety of important functions in controlling and shaping the immune response. One of these functions is immune-mediated cell death, and it is carried out by two major subtypes: CD8+ "killer" (cytotoxic) and CD4+ "helper" T cells. Regulatory T cells are yet another distinct population of T cells that provide the critical mechanism of tolerance, whereby immune cells are able to distinguish invading cells from "self".
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc)
TMPY-02726
RANKL TNFSF11 CD254 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56 kDa and the accession number is AAC40113.1.
- $235
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TLR2 Protein, Human, Recombinant (aa 1-587, His)
TMPY-02794
TLR2 Protein, Human, Recombinant (aa 1-587, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 65.5 kDa and the accession number is O60603-1.
- $386
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TLR4 Protein, Human, Recombinant (His)
TMPY-02904
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. TLR 4 has also been designated as CD284 (cluster of differentiation 284). It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). It acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. It is also involved in LPS-independent inflammatory responses triggered by Ni(2+).
- $386
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CD39 Protein, Human, Recombinant (His)
TMPY-01126
CD39 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 51.8 kDa and the accession number is P49961-1.
- $255
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CD16a Protein, Human, Recombinant (F176V, His)
TMPY-01964
The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes macrophages, natural killer (NK) cells, and a subset of T cells._x000D_ CD16a FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a FCGR3A also has a broader function. CD16a FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.
- $386
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CD73 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-06907
CD73 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 61.04 kDa and the accession number is NP_002517.1.
- $600
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RANKL/TNFSF11/CD254 Protein, Human, Recombinant
TMPY-03364
RANKL TNFSF11 CD254 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 20.5 kDa and the accession number is AAC51762.1.
- $296
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RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc)
TMPY-03527
RANKL TNFSF11 CD254 Protein, Human, Recombinant (aa 63-244, rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 47.9 kDa and the accession number is O14788-2.
- $618
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CD83 Protein, Human, Recombinant (His)
TMPY-01829
CD83 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.5 kDa and the accession number is Q01151-1.
- $386
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PD-1 Protein, Human, Recombinant (hFc)
TMPY-04898
PD-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession number is A0A0M3M0G7.
- $172
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CD73 Protein, Mouse, Recombinant (His)
TMPY-01342
CD73 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.4 kDa and the accession number is Q0VEE0.
- $228
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CD40 Ligand Protein, Human, Recombinant (hFc)
TMPY-02022
CD40 Ligand Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.8 kDa and the accession number is P29965.
- $197
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RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
TMPJ-00662
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
- $118
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CD28 Protein, Human/Cynomolgus, Recombinant (His)
TMPJ-00103
CD28 Protein, Human Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is P10747.
- $56
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Fas Ligand Protein, Human, Recombinant (His)
TMPY-03956
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6 FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6 FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 19.3 kDa and the accession number is P48023-1.
- $335
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CD38 Protein, Human, Recombinant (His)
TMPY-01023
CD38 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.3 kDa and the accession number is P28907-1.
- $313
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RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)
TMPJ-00607
RANKL TNFSF11 CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1.
- $118
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PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00181
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28 CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
- $355
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4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (hFc)
TMPJ-00145
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9 4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
- $110
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RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)
TMPJ-01472
RANKL TNFSF11 CD254 Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 23-29 KDa and the accession number is O35235-1.
- $260
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DPP4/CD26 Protein, Human, Recombinant
TMPY-00779
DPP4 CD26 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 85.4 kDa and the accession number is P27487.
- $451
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CD73 Protein, Human, Recombinant (His)
TMPY-01851
CD73 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is P21589-1.
- $416
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CD40 Ligand Protein, Rat, Recombinant (hFc)
TMPY-03301
CD40 Ligand Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is Q9Z2V2.
- $462
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DPP4/CD26 Protein, Mouse, Recombinant (hFc)
TMPY-00221
DPP4 CD26 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 112.9 kDa and the accession number is P28843.
- $221
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CD16a Protein, Rat, Recombinant (His)
TMPY-02018
CD16a Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.7 kDa and the accession number is A0A8L2QKY4.
- $386
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PD-1 Protein, Mouse, Recombinant (hFc)
TMPY-05395
PD-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.9 kDa and the accession number is Q02242.
- $113
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DPP4/CD26 Protein, Human, Recombinant (His)
TMPY-00122
DPP4 CD26 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.3 kDa and the accession number is P27487.
- $740
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CD8A & CD8B Heterodimer Protein, Human, Recombinant (Flag & His)
TMPY-05669
CD8A & CD8B Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 44.1 kDa and the accession number is NP_001759.3&NP_004922.1.
- $320
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IL-18R alpha Protein, Cynomolgus, Recombinant (His)
TMPY-00509
IL-18R alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.6 kDa and the accession number is F7H8F9.
- $600
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Fas/CD95 Protein, Cynomolgus, Recombinant
TMPY-00632
Fas CD95 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 17.6 kDa and the accession number is F6V1W6.
- $600
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CD1D & B2M Heterodimer Protein, Human, Recombinant (His)
TMPY-02854
CD1D & B2M Heterodimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45 kDa and the accession number is P15813&P61769.
- $451
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ICOS Protein, Rat, Recombinant (hFc)
TMPY-03311
ICOS Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.7 kDa and the accession number is Q9R1T7-1.
- $600
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TM4SF2/TSPAN7 Protein, Cynomolgus, Recombinant (mFc)
TMPY-03930
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4SF2 TSPAN7 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 38.2 kDa and the accession number is Q4R5A3.
- $700
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DPP4/CD26 Protein, Cynomolgus, Recombinant (hFc)
TMPY-03952
DPP4 CD26 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 112.9 kDa and the accession number is F6VRB0.
- $498
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PD-1 Protein, Rat, Recombinant (His)
TMPY-04341
PD-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is A6JR44.
- $600
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CD8A & CD8B Heterodimer Protein, Cynomolgus, Recombinant (Flag & His)
TMPY-06257
CD8A & CD8B Heterodimer Protein, Cynomolgus, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 44.27 kDa and the accession number is XP_001092778.2&XP_005575417.1.
- $600
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CD30L Protein, Human, Recombinant (hFc)
TMPY-00705
CD30L Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.8 kDa and the accession number is P32971.
- $451
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Fas/CD95 Protein, Human, Recombinant (His)
TMPY-01704
Fas CD95 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.2 kDa and the accession number is P25445-1.
- $600
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PD-1 Protein, Human, Recombinant (His)
TMPY-00897
PD-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession number is A0A0M3M0G7.
- $295
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PD-1 Protein, Human, Recombinant (His & hFc)
TMPY-00896
PD-1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 43.84 kDa and the accession number is A0A0M3M0G7.
- $244
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4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His)
TMPY-01743
4-1BB CD137 TNFRSF9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.8 kDa and the accession number is Q07011.
- $222
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RANKL/TNFSF11/CD254 Protein, Human, Recombinant (hFc)
TMPY-01471
RANKL TNFSF11 CD254 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is AAC51762.1.
- $383
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CD25/IL2R alpha Protein, Human, Recombinant (His)
TMPY-01103
CD25 IL2R alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01589.
- $320
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IL-6R Protein, Mouse, Recombinant (His)
TMPY-01214
IL-6R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39 kDa and the accession number is P22272.
- $386
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CD8 alpha Protein, Ferret, Recombinant (His)
TMPY-02165
CD8 alpha Protein, Ferret, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.5 kDa and the accession number is I6LI23.
- $700
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CD73 Protein, Rat, Recombinant (His)
TMPY-03540
CD73 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.4 kDa and the accession number is Q66HL0.
- $451
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Fas/CD95 Protein, Mouse, Recombinant (His)
TMPY-01426
Fas CD95 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is P25446.
- $600
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PD-1 Protein, Canine, Recombinant (His)
TMPY-04342
PD-1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is XP_022265285.1.
- $386
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