E3 Ligase Ligand-Linker Conjugate

Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon ligand and a linker used in [PROTAC] technology.

Thalidomide-PEG4-Propargyl (Thalidomide-O-PEG4-Propargyl) is a synthetic E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker which can be used in PROTAC technology[1].

Pomalidomide 4'-PEG2-azide is a synthetic E3 ligase ligand-linker conjugate, comprising a Pomalidomide-based cereblon ligand and a linker.

Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) is a synthetic E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker[1].

Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

Pomalidomide-PEG1-CO2H is a synthetic E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker.

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker. This compound is used in the synthesis of PROTACs.

Thalidomide 4'-ether-alkylC2-amine hydrochloride (halidomide-linker 6) is a synthesized E3 ligase ligand-linker conjugate.

Pomalidomide-PEG2-CO2H is a synthetic E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker.

Thalidomide-O-amido-PEG2-C2-NH2 TFA (E3 Ligase Ligand-Linker Conjugates 24 TFA) is a synthesized E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a 2-unit PEG linker, utilized in PROTAC technology.

Thalidomide-linker 9 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate that integrates the (S,R,S)-AHPC-based VHL ligand with a 3-unit PEG linker.

Pomalidomide 4'-PEG3-azide is a chemically synthesized E3 ligase ligand-linker conjugate that incorporates the cereblon ligand derived from Pomalidomide, along with a linker. This compound is utilized in the synthesis of iRucaparib-TP3 (Compound 3), an effective PARP1 degrader developed through the PROTAC strategy and derived from Rucaparib.

Pomalidomide-PEG3-CO2H (Thalidomide-NH-PEG3-propionic acid) is a synthesized E3 ligase ligand-linker conjugate. Pomalidomide-PEG3-CO2H incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

Thalidomide-O-amido-C4-NH2 TFA (E3 ligase Ligand-Linker Conjugates 19 TFA) is a synthesized compound that functions as an E3 ligase ligand-linker conjugate.

Pomalidomide-C3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that integrates the Pomalidomide-based CRBN ligand and linker used in PROTAC technology.

Thalidomide-O-amido-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 3 (TFA)) is a synthesized E3 ligase ligand-linker conjugate incorporating a Thalidomide-based cereblon ligand and a 3-unit PEG linker, used in PROTAC technology.

(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) is a synthesized E3 ligase ligand-linker conjugate that includes the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker used in the synthesis of PROTAC.

Thalidomide-NH-C4-NH-Boc is a synthesized conjugate used in PROTAC technology, combining a Thalidomide-based cereblon ligand with a linker.

Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) is a synthesized E3 ligase ligand-linker conjugate incorporating a Thalidomide-based cereblon ligand and a linker used in PROTAC technology.

Thalidomide-O-amido-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, integrating a Thalidomide-based cereblon ligand with a linker, suitable for PROTAC synthesis.

Thalidomide-O-C6-NH2 hydrochloride (4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride) is a synthesized E3 ligase ligand-linker conjugate.

Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) is an E3 ligase ligand-linker conjugate.

(S,R,S)-AHPC-C3-NH2 hydrochloride (VH032-C3-NH2 hydrochloride) is an E3 ligase ligand-linker coupler that can be used for the synthesis of PROTAC compounds.

Pomalidomide-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.

(S,R,S)-AHPC-PEG2-NH2 (VHL Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate, incorporating the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker used in PROTAC synthesis.

E3 Ligase Ligand-linker Conjugate 149 is an E3 ubiquitin ligase ligand-linker conjugate, and it is used in the synthesis of Setidegrasib.

E3 Ligase Ligand-linker Conjugate 147 is a conjugate of an E3 ligase ligand and a PROTAC linker, utilized in the synthesis of BRD9 Degrader-1 (Compound 13-7). Comprising the E3 ligase ligand BRD9 ligand-7 and the PROTAC linker 2-((1R,5S,6s)-3-Azabicyclo[3.1.0]hexan-6-yl)ethan-1-ol, this conjugate plays a critical role in biochemical applications.

E3 Ligase Ligand-linker Conjugate 148 is a conjugate used in the synthesis of PROTACs, consisting of an E3 ligase ligand and a linker.

E3 Ligase Ligand-linker Conjugate 122 (Compound 2c) is a conjugate of an E3 ligase ligand and a linker, utilized for the synthesis of the PROTAC degrader NR-11c.

L321-NH-C3-PEG3-C1-NH2 is a conjugation of the E3 ligase ligand and linker found in BRD4 PROTAC L134.

Thalidomide-NH-C2-2-azaspiro[3.3]heptane is a conjugate of an E3 ubiquitin ligase ligand and a linker, designed for the synthesis of KT-413.

E3 Ligase Ligand-linker Conjugate 150 is a conjugate consisting of a ligand for the E3 ligase VHL and a linker, and it is utilized in the synthesis of PROTAC SMARCA2 degrader-32.

Thalidomide-piperidine-C2-piperazine-Boc is an E3 Ligase Ligand-linker conjugate comprising a cereblon ligand based on Thalidomide and a linker. This compound is utilized in the synthesis of PROTAC.

E3 Ligase Ligand-linker Conjugate 142 is a conjugate comprised of an E3 ubiquitin ligase ligand and a linker, utilized in the synthesis of CFT8634.

Bestatin-amide-PEG3-CH2-acid is an E3 Ligase Ligand-linker conjugate. It is utilized in the synthesis of PROTACRAR Degrader-1.

(S,R,S)-AHPC-CO-PEG-C2-iodine is an E3 ligase (VHL) ligand-linker conjugate used in the synthesis of PROTACs, such as PROTACFAK degrader 1.

OICR-8268-acrylic acid-amino-PEG9-amine is an E3 Ligase Ligand-linker conjugate. This compound is utilized for the synthesis of OICR41114.

2-(2-Aminoethoxy)ethyl 2-(adamantan-1-yl) acetate is a conjugate of the hydrophobic group Hyt with a linker, utilized in the synthesis of SARD279.

(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-C-Pip is a conjugate of an E3 ubiquitin ligase ligand and a linker, employed in the synthesis of PROTACFHD-609.

E3 Ligase Ligand-linker Conjugate 143 is a compound consisting of an E3 ubiquitin ligase ligand and a linker, used for synthesizing ACBI3.

(S,R,S)-AHPC-CO-C4-bromine is a compound used in the synthesis of PROTACs, serving as an E3 ligase ligand-linker conjugate. It consists of an E3 ligase ligand coupled with a linker.

E3 Ligase Ligand-linker Conjugate 141 is a combination of an E3 ubiquitin ligase ligand and a linker, utilized in the synthesis of PROTACER Degrader-12.

E3 Ligase Ligand-linker Conjugate 151 is a conjugate of an E3 ligase ligand and a linker. It is utilized in the synthesis of PROTAC SMARCA2 4 degrader-36.

Lenalidomide-Glycolic acid is a conjugate of an E3 ligase ligand and a linker, used in the synthesis of the PROTAC-type FLT3 degrader LWY713.

(S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is a conjugate that serves as both an E3 ubiquitin ligase ligand and a linker for NX-2127.

CCW16-C4-NHBoc is the conjugate of an E3 ligase ligand and linker for BRD4 PROTAC CCW 28-3.