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Thalidomide-O-amido-PEG2-C2-NH2 TFA

Thalidomide-O-amido-PEG2-C2-NH2 TFA
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Purity:97.13%
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Thalidomide-O-amido-PEG2-C2-NH2 TFA

Catalog No. T17918Cas No. 1957235-75-4
Thalidomide-O-amido-PEG2-C2-NH2 TFA (E3 Ligase Ligand-Linker Conjugates 24 TFA) is a synthesized E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a 2-unit PEG linker, utilized in PROTAC technology.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$33In Stock
2 mg$47In Stock
5 mg$75In Stock
10 mg$108In Stock
25 mg$183In Stock
50 mg$272In Stock
100 mg$396In Stock
200 mg$743In Stock
500 mg$1,450In Stock
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Product Introduction

Bioactivity
Description
Thalidomide-O-amido-PEG2-C2-NH2 TFA (E3 Ligase Ligand-Linker Conjugates 24 TFA) is a synthesized E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a 2-unit PEG linker, utilized in PROTAC technology.
In vitro
PROTACs consist of two ligands linked together: one binds to an E3 ubiquitin ligase, and the other targets a specific protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs facilitate the selective degradation of target proteins [1].
AliasE3 Ligase Ligand-Linker Conjugates 24 TFA, Cereblon Ligand-Linker Conjugates 10 TFA
Chemical Properties
Molecular Weight576.48
FormulaC23H27F3N4O10
Cas No.1957235-75-4
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 150 mg/mL (260.20 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.7347 mL8.6733 mL17.3467 mL86.7333 mL
5 mM0.3469 mL1.7347 mL3.4693 mL17.3467 mL
10 mM0.1735 mL0.8673 mL1.7347 mL8.6733 mL
20 mM0.0867 mL0.4337 mL0.8673 mL4.3367 mL
50 mM0.0347 mL0.1735 mL0.3469 mL1.7347 mL
100 mM0.0173 mL0.0867 mL0.1735 mL0.8673 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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