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(S,R,S)-AHPC-PEG2-NH2 hydrochloride
🥰Excellent
Catalog No. T17924Cas No. 2097973-72-1
Alias VHL Ligand-Linker Conjugates 3 hydrochloride, VH032-PEG2-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 6
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) is a synthesized E3 ligase ligand-linker conjugate that includes the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker used in the synthesis of PROTAC.
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
🥰Excellent
Purity: 99.29%
Catalog No. T17924Alias VHL Ligand-Linker Conjugates 3 hydrochloride, VH032-PEG2-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 6Cas No. 2097973-72-1
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) is a synthesized E3 ligase ligand-linker conjugate that includes the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker used in the synthesis of PROTAC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $34 | In Stock | |
| 10 mg | $55 | In Stock | |
| 25 mg | $113 | In Stock | |
| 50 mg | $178 | In Stock | |
| 100 mg | $255 | In Stock | |
| 500 mg | $639 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $55 | In Stock |
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(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
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Purity:99.29%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | (S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) is a synthesized E3 ligase ligand-linker conjugate that includes the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker used in the synthesis of PROTAC. |
| In vitro | PROTACs consist of two ligands joined by a linker: one targets an E3 ubiquitin ligase, and the other targets the desired protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade these target proteins[1]. |
| Alias | VHL Ligand-Linker Conjugates 3 hydrochloride, VH032-PEG2-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 6 |
| Molecular Weight | 612.18 |
| Formula | C28H42ClN5O6S |
| Cas No. | 2097973-72-1 |
| Smiles | O=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (163.35 mM), Sonication is recommended. H2O: 100 mg/mL (163.35 mM ), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
VHL Ligand-Linker Conjugates 3 HydrochlorideVHL Ligand-Linker Conjugates 3VH032-PEG2-NH2 HydrochlorideInhibitorinhibitE3LigaseLigandLinkerConjugateE3 Ligase Ligand-Linker ConjugatesE3 Ligase LigandLinker ConjugateAHPC-PEG2-NH2 Hydrochloride(S,R,S)-AHPC-PEG-2-NH2 hydrochloride(S,R,S)AHPCPEG2NH2 hydrochloride(S,R,S) AHPC PEG2 NH2 hydrochloride
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