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Thalidomide-O-amido-PEG-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker. This compound is used in the synthesis of PROTACs.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | 29 € | In Stock | |
10 mg | 41 € | In Stock | |
25 mg | 69 € | In Stock | |
50 mg | 101 € | In Stock | |
1 mL x 10 mM (in DMSO) | 36 € | In Stock |
Description | Thalidomide-O-amido-PEG-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker. This compound is used in the synthesis of PROTACs. |
In vitro | PROTACs consist of two ligands joined by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. They leverage the intracellular ubiquitin-proteasome system to selectively degrade these target proteins [1]. |
Molecular Weight | 454.862 |
Formula | C19H23ClN4O7 |
Cas No. | 2204226-02-6 |
Smiles | Cl.NCCOCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 100 mg/mL (219.85 mM), Sonication is recommended. DMSO: 125 mg/mL (274.81 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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