Antioxidant

Deferoxamine（Desferrioxamine B） is an iron chelator (binds Fe(III) and many other metal cations) that inhibits neuronopathy, may be used to modify the reduction of iron accumulation and deposition in tissues, and may improve neurological dysfunction by inhibiting ferroptosis and neuroinflammation following traumatic brain injury.Desferrioxamin-B has antioxidant, antiproliferative, Deferoxamine has antioxidant, antiproliferative, and antitumor activities, and can induce HIF-1α production, apoptosis and autophagy in cancer cells.Desferrioxamin-B can be used in the treatment of acute iron toxicity and COVID-19 related diseases.

Etomoxir is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that inhibits fatty acid oxidation by inhibiting CPT-1a and inhibits palmitate oxidation in humans, rats, and guinea pigs. Etomoxir has an inhibitory effect on adenine nucleotide translocase and can inhibit macrophage polarization by disrupting CoA homeostasis.

(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) is a natural product isolated from tea leaves with potent antioxidant, cytotoxic, and antibacterial properties, and it improves the adhesive stability of etching rinsing adhesives to dentin.

LDL-IN-3 shows anti-atherosclerotic and antioxidant activities.

Nordihydroguaiaretic acid (NDGA) is a natural product, extracted from Pole Fork Kelaroa, and is a lipoxygenase (5-LOX) inhibitor (IC50=8 μM). Nordihydroguaiaretic acid possesses antioxidant and free radical scavenging properties.

AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine in PANC-1 cells.

Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.

Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.

1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation in vitro and suppresses Ti particle

Pachypodol, a methoxyflavonoid isolated from Pogostemon cablin Bentham, has antioxidant and cytoprotective properties and inhibits the growth of CaCo 2 colon cancer cell lines in vitro.Pachypodol protects neonatal rats from anesthesia-induced apoptosis in the developing brain through modulation of the JNK ERK pathway.PDGFRα kinase inhibitory activity in macrophages exposed to STING agonists.

Ergothioneine (L-(+)-Ergothioneine) is synthesized by certain bacteria and fungi. It is generally considered an antioxidant.

[10]-Shogaol (10-Shogaol) is an extract from ginger displaying antioxidant activity. It also may contain hypolipidemic and insulin-sensitizing effects.

Aureusidin (Auresidin) shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.

Oleoylestrone (MP-101) is present in plasma and adipose tissue, has potential antioxidant effects, induces loss of body fat in rats, and can be used for weight loss.

Chrysin-7-O-glucuronide (Chrysin 7-O-beta-D-glucopyranuronoside) is a natural product, with antioxidant activity

Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

Sanguinarine (Pseudochelerythrine) is a specific inhibitor of Rac1b with anti-microbial, anti-oxidant and anti-inflammatory properties.

Isoliensinine (Isoliensinin) is a natural product, a bisbenzylisoquinoline alkaloid. Isoliensinine has antitumor, antioxidant, anti-inflammatory, and antiarrhythmic activities.

Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apoptosis by inhibiting Ca2+ in-flux and modulating gene expression in the Ca2+-CaMKII-CREB signalling pathway.

D609 (Tricyclodecan-9-yl-Xanthogenate) has a wide range of biological activities including antioxidant, antiapoptotic, anticholinergic, antitumor, anti-inflammatory, antiviral, antiproliferative, and neuroprotective activities.D609 acts by inducing competitive inhibition of PC-specific phospholipase C (PC-PLC) and sphingomyelin synthase (SMS). D609 acts by causing competitive inhibition of PC-specific phospholipase C (PC-PLC) and sphingomyelin synthase (SMS).

Salviaflaside is the main bioactive component of Prunella vulgaris and has antioxidant activity.

Zeaxanthin is a dietary carotenoid that accumulates in the retina (particularly the macula) and has antioxidant activity that may improve obesity, prevent age-related macular degeneration, and protect against nonalcoholic steatohepatitis.

BMY-21502 is a potential cognitive enhancer that shows anti-hypoxia effects in the KCN-hypoxia model, delays the decay of hippocampal synaptic enhancement in vitro, and can be used to study Alzheimer's disease.

3,4-Dicaffeoylquinic acid (Isochlorogenic acid B) has antioxidant activity.

S-Allylmercaptocysteine HCl is an organosulfur compound isolated from aged garlic with anti-inflammatory, antioxidant, anticancer, and antitumor activities.S-Allylmercaptocysteine HCl inhibits inflammation in COPD and targets Nrf2 in osteoarthritis therapy through the NOX4 NF-kappaB pathway. Targeting Nrf2.

Diosmetin-7-O-β-D-glucopyranoside (Eridictiol) exhibits antioxidant activity.

Cyanidin Chloride, the main phenolic antioxidant in the grape (Vitis vinifera), in particular in the liposomal forms, could be used for treatment of diabetes mellitus complications.

Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor with IC50 values of 1.07, 6.03, and 8.55 μM, respectively.Epiberberine chloride has antioxidant effects and inhibits the effects of Ca9-22 and Fa2R. Epiberberine chloride has antioxidant effects, inhibits the motility of Ca9-22 and FaDu cell lines, and can be used to study hyperlipidemia, Alzheimer's disease and diabetes.

1. Nepitrin (Nepetin-7-glucoside) has antioxidant activity in human HL6 cells assessed as reduction of cytochrome-c release, DPPH free radical scavenging activity, and inhibition of TPA-induced free radical formation.

Spathulenol is a natural ingredient from Aristolochia yunnanensis that has anti-inflammatory, antioxidant, anti-proliferation, anti-ulcer and anti-mycobacterium activities. Spathulenol showed significant antioxidant activity in DPPH system with IC50 of 85.60 μg mL.

Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory and hepatoprotective effects.

Crocetine dimethyl ester (Dimethylcrocetin) is a saffronin derivative exhibiting antioxidant properties, inhibition of AChE activity, and suppression of cell growth and differentiation.

1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.

Cynarin (1,5-Dicaffeoylquinic acid) has neuroprotective, and antioxidant effects, it can inhibition of GSK3β as well as the modulation of Bcl-2 Bax.

Butylated hydroxytoluene (BHT FCC NF) is an antioxidant widely used in food, cosmetics and industrial liquids. It is a ferroptosis inhibitor.

DiosMetin 7-O-β-D-Glucuronide, an antioxidant constituent found in the fruits of Luffa cylindrical, supplies antioxidant benefits when sponge gourds are consumed.

Pinobanksin 3-acetate (3-O-Acetylpinobanksin), a flavonoid derivative, is a strong antioxidant found in sunflowers and honey that inhibits LDL peroxidation.

6-Hydroxy-2-phenethylchromone (6-Hydroxy-2-(2-phenylethyl)chromone) is a compound isolated from Aquilaria sinensis, which has antioxidant activity.

Melittoside is a natural phenolic glycoside found in the nectar of the Melitto genus. It has antioxidant, anti-inflammatory and antifungal activities, as well as research into its potential use in the treatment of various diseases, including cancer, diabetes and cardiovascular disease.

Dieckol, a rhizomycin found in some brown algae species, has antimicrobial, anticancer, antioxidant, antiaging, antidiabetic, and neuroprotective effects, ameliorates acute hearing loss, and inhibits cell proliferation through cell cycle arrest in human tracheal fibroblasts via Hs680.Tr.

DL-Syringaresinol ( (±)-Syringaresinol) is a lignan from ginseng berries with anti-inflammatory, antioxidant, analgesic and weak anti-mycobacterial activities.DL-Syringaresinol can delay oxidative stress-induced skin aging through autophagy, alleviate oxaliplatin-induced neuropathic pain and sepsis-induced cardiac dysfunction by inhibiting inflammatory responses. neuropathic pain and sepsis-induced cardiac dysfunction by inhibiting inflammatory responses.

Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.

Adrenochrome (Adraxone) is a cytotoxic molecule that can be used to kill bacteria. Adrenochrome is an oxidized product of Epinephrine. Adrenochrome is a coronary systolic compound that acts on rat hearts and is associated with cardiotoxicity and can be used to determine superoxide dismutase activity. Adrenochrome is a potential psychotropic drug for the study of nervous system diseases.

Kukoamine B, as a constituent of Lycii Cortex, exhibits anti-acute inflammatory, anti-oxidant, and anti-diabetic characteristics.

Cyanidin-3-O-galactoside chloride (Ideain chloride), extracted from hawthorn pericarp (EPHF), possesses antioxidant activity and is applicable in obesity research.

1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.

AEOL-10150 pentachloride is a metalloporphyrin catalytic antioxidant and superoxide dismutase mimetic that protects lungs from radiation-induced injury.

Astragaloside III has cardioprotective effects as well as causing improvement in cognitive function. It can be used in the prevention of cardio-cerebral vascular diseases. It also is antioxidant.