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Gossypetin
🥰Excellent
Catalog No. TN1711Cas No. 489-35-0
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects.It inhibits bone resorption by downregulating lysosomal caspase K activity and inducing autophagy-associated proteins in actin ring osteoclasts. Gossypetin has anti-mutagenic, anti-atherosclerotic, anti-oxidant, cytoprotective and antibacterial effects, and it inhibits bone resorption by down-regulating lysosomal caspase K activity and by inducing autophagy-associated protein in actin ring osteoblasts.
Gossypetin
🥰Excellent
Purity: 95%
Catalog No. TN1711Cas No. 489-35-0
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects.It inhibits bone resorption by downregulating lysosomal caspase K activity and inducing autophagy-associated proteins in actin ring osteoclasts. Gossypetin has anti-mutagenic, anti-atherosclerotic, anti-oxidant, cytoprotective and antibacterial effects, and it inhibits bone resorption by down-regulating lysosomal caspase K activity and by inducing autophagy-associated protein in actin ring osteoblasts.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 210 € | In Stock | |
| 5 mg | 525 € | In Stock | |
| 10 mg | 749 € | In Stock | |
| 25 mg | 1.121 € | In Stock | |
| 50 mg | 1.510 € | In Stock |
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Purity:95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects.It inhibits bone resorption by downregulating lysosomal caspase K activity and inducing autophagy-associated proteins in actin ring osteoclasts. Gossypetin has anti-mutagenic, anti-atherosclerotic, anti-oxidant, cytoprotective and antibacterial effects, and it inhibits bone resorption by down-regulating lysosomal caspase K activity and by inducing autophagy-associated protein in actin ring osteoblasts. |
| In vitro | Gossypetin (60 μM; 3 h; KYSE30 and KYSE410 cells) strongly inhibits p38 activity in a dose-dependent manner and demonstrates that Gossypetin directly inhibits MKK3 or MKK6 activity. [1] Gossypetin (20-60 μM; 48 h; KYSE30, KYSE450, and KYSE510 cells) strongly inhibits anchorage-dependent esophageal cancer cell growth in a dose-dependent manner. [1] Gossypetin (20-40 μM; 48 h; KYSE450 and KYSE510 cells) reduces the S phase and induces cell cycle arrest in the G2 phase in a dose-dependent manner. [1] Gossypetin (20-40 μM; 72 h; esophageal carcinoma cells) induces intrinsic apoptosis in esophageal carcinoma cells. [1] |
| In vivo | Gossypetin (100 mg/kg; p.o.; 5 times a week; for 21 days; (SCID) female mice) leads to a notable reduction in the growth volume of esophageal tumors, while not causing a significant decline in body weight. Moreover, Gossypetin induces a notable decrease in Ki67 expression. Observable morphological distinctions between mouse tissues in treated and untreated groups were absent. Furthermore, Gossypetin treatment strongly suppresses the phosphorylation of p38, an immediate downstream protein of MKK3/6.[1] |
| Molecular Weight | 318.24 |
| Formula | C15H10O8 |
| Cas No. | 489-35-0 |
| Smiles | Oc1ccc(cc1O)-c1oc2c(O)c(O)cc(O)c2c(=O)c1O |
| Relative Density. | 1.912 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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