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Succinobucol

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Purity:98.8%

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COA HNMR HPLC

Succinobucol

Catalog No. T4287Cas No. 216167-82-7

Succinobucol (Probucol monosuccinate) is a novel phenolic antioxidant small molecule with anti-oxidant and anti-inflammatory properties. It designed to treat atherosclerosis of the blood vessels of the heart or coronary artery disease.

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Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$80	In Stock
25 mg	$163	In Stock
50 mg	$278	In Stock
100 mg	$476	In Stock
500 mg	$1,050	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock

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Product Introduction

Bioactivity

Description	Succinobucol (Probucol monosuccinate) is a novel phenolic antioxidant small molecule with anti-oxidant and anti-inflammatory properties. It designed to treat atherosclerosis of the blood vessels of the heart or coronary artery disease.
In vitro	In rabbit whole blood, Succinobucol (10, 50, 100 μM) causes a dose-dependent reduction in collagen-induced platelet aggregation. Succinobucol (10, 100 μM) significantly lowers the relaxation to X/XO.
In vivo	In lung metastatic breast cancer mice, Succinobucol (40 mg/kg) by tail injection significantly reduces the average number of metastatic nodules. In rats, Succinobucol (50, 100, and 150 mg/kg, i.v.) has no significant effect on either heart rate or MAP.
Cell Research	In the metastatic 4T1 breast cancer cells, Succinobucol, SCB and the PCD polymer (equivalent concentration to SCB) are respectively added to each well with SCB concentrations ranging from 4 ng/mL to 40 μg/mL.
Animal Research	Mice, injected 4T1-luc cells, are treated with Succinobucol (40 mg/kg) by tail injection every three days.
Alias	Probucol monosuccinate, AGI-1067

Chemical Properties

Molecular Weight	616.91
Formula	C35H52O5S2
Cas No.	216167-82-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (72.94 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6210 mL	8.1049 mL	16.2098 mL	81.0491 mL
5 mM	0.3242 mL	1.6210 mL	3.2420 mL	16.2098 mL
10 mM	0.1621 mL	0.8105 mL	1.6210 mL	8.1049 mL
20 mM	0.0810 mL	0.4052 mL	0.8105 mL	4.0525 mL
50 mM	0.0324 mL	0.1621 mL	0.3242 mL	1.6210 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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